@article {318888,
	title = {Neocortical Expansion Due to Increased Proliferation of Basal Progenitors Is Linked to Changes in Their Morphology.},
	journal = {Cell Stem Cell},
	volume = {24},
	year = {2019},
	month = {2019 Apr 04},
	pages = {535-550.e9},
	abstract = {<p>The evolutionary expansion of the mammalian neocortex (Ncx) is thought to be linked to increased proliferative capacity of basal progenitors (BPs) and their neurogenic capacity. Here, by quantifying BP\&nbsp;morphology in the developing Ncx of mouse, ferret, and human, we show that increased BP proliferative capacity is linked to an increase in BP process number. We identify human membrane-bound PALMDELPHIN (PALMD-Caax) as an underlying factor, and we show that it drives BP process growth and proliferation when expressed in developing mouse and ferret Ncx. Conversely, CRISPR/Cas9-mediated disruption of PALMD or its binding partner ADDUCIN-γ in fetal human Ncx reduces BP process numbers and proliferation. We further show that PALMD-induced processes enable BPs to receive pro-proliferative integrin-dependent signals. These findings provide a link between BP morphology and proliferation, suggesting that changes in BP morphology may have contributed to the evolutionary expansion of the Ncx.</p>
},
	issn = {1875-9777},
	doi = {10.1016/j.stem.2019.02.017},
	author = {Kalebic, N and Gilardi, C and Stepien, B and Wilsch-Br{\"a}uninger, M and Long, KR and Namba, T and Florio, M and Langen, B and Lombardot, B and Shevchenko, A and Kilimann, MW and Kawasaki, H and Wimberger, P and Huttner, WB}
}
