@article {324697,
	title = {Philippine Ayta possess the highest level of Denisovan ancestry in the world},
	journal = {Current Biology},
	year = {2021},
	note = {<p>doi: 10.1016/j.cub.2021.07.022</p>
},
	month = {08/2021},
	abstract = {<p>Multiple lines of evidence show that modern humans interbred with archaic Denisovans. Here, we report an account of shared demographic history between Australasians and Denisovans distinctively in Island Southeast Asia. Our analyses are based on ?2.3 million genotypes from 118 ethnic groups of the Philippines, including 25 diverse self-identified Negrito populations, along with high-coverage genomes of Australopapuans and Ayta Magbukon Negritos. We show that Ayta Magbukon possess the highest level of Denisovan ancestry in the world??30\%?40\% greater than that of Australians and Papuans?consistent with an independent admixture event into Negritos from Denisovans. Together with the recently described Homo luzonensis, we suggest that there were multiple archaic species that inhabited the Philippines prior to the arrival of modern humans and that these archaic groups may have been genetically related. Altogether, our findings unveil a complex intertwined history of modern and archaic humans in the Asia-Pacific region, where distinct Islander Denisovan populations differentially admixed with incoming Australasians across multiple locations and at various points in time.Multiple lines of evidence show that modern humans interbred with archaic Denisovans. Here, we report an account of shared demographic history between Australasians and Denisovans distinctively in Island Southeast Asia. Our analyses are based on ?2.3 million genotypes from 118 ethnic groups of the Philippines, including 25 diverse self-identified Negrito populations, along with high-coverage genomes of Australopapuans and Ayta Magbukon Negritos. We show that Ayta Magbukon possess the highest level of Denisovan ancestry in the world??30\%?40\% greater than that of Australians and Papuans?consistent with an independent admixture event into Negritos from Denisovans. Together with the recently described Homo luzonensis, we suggest that there were multiple archaic species that inhabited the Philippines prior to the arrival of modern humans and that these archaic groups may have been genetically related. Altogether, our findings unveil a complex intertwined history of modern and archaic humans in the Asia-Pacific region, where distinct Islander Denisovan populations differentially admixed with incoming Australasians across multiple locations and at various points in time.</p>
},
	isbn = {0960-9822},
	doi = {https://doi.org/10.1016/j.cub.2021.07.022},
	url = {https://www.cell.com/current-biology/fulltext/S0960-9822(21)00977-5},
	author = {Larena, Maximilian and McKenna, James and Sanchez-Quinto, Federico and Bernhardsson, Carolina and Ebeo, Carlo and Reyes, Rebecca and Casel, Ophelia and Huang, Jin-Yuan and Hagada, Kim Pullupul and Guilay, Dennis and Reyes, Jennelyn and Allian, Fatima Pir and Mori, Virgilio and Azarcon, Lahaina Sue and Manera, Alma and Terando, Celito and Jamero, Lucio, Jr. and Sireg, Gauden and Manginsay-Tremedal, Renefe and Labos, Maria Shiela and Vilar, Richard Dian and Latiph, Acram and Saway, Rodelio Linsahay and Marte, Erwin and Magbanua, Pablito and Morales, Amor and Java, Ismael and Reveche, Rudy and Barrios, Becky and Burton, Erlinda and Salon, Jesus Christopher and Kels, Ma. Junaliah Tuazon and Albano, Adrian and Cruz-Angeles, Rose Beatrix and Molanida, Edison and Graneh{\"a}ll, Lena and Vicente, M{\'a}rio and Edlund, Hanna and Loo, Jun-Hun and Trejaut, Jean and Ho, Simon Y.W. and Reid, Lawrence and Lambeck, Kurt and Malmstr{\"o}m, Helena and Schlebusch, Carina and Endicott, Phillip and Jakobsson, Mattias}
}
