@article {328371,
	title = {A weakly structured stem for human origins in Africa.},
	journal = {Nature},
	year = {2023},
	month = {2023 May 17},
	abstract = {<p>Despite broad agreement that Homo sapiens originated in Africa, considerable uncertainty surrounds specific models of divergence and migration across the continent. Progress is hampered by a shortage of fossil and genomic data, as well as variability in previous estimates of divergence times. Here we seek to discriminate among such models\&nbsp;by considering linkage disequilibrium and diversity-based statistics, optimized for rapid, complex demographic inference. We infer detailed demographic models for populations across Africa, including eastern and western representatives, and newly sequenced whole genomes from 44 Nama (Khoe-San) individuals from southern Africa. We infer a reticulated African population history in which present-day population structure dates back to Marine Isotope Stage 5. The earliest population divergence among contemporary populations occurred 120,000 to\&nbsp;135,000 years ago and was preceded by links between two or more weakly differentiated ancestral Homo populations connected by gene flow over hundreds of thousands of years. Such weakly structured stem models explain patterns of polymorphism that had previously been attributed to contributions from archaic hominins in Africa. In contrast to models with archaic introgression, we predict that fossil remains from coexisting ancestral populations should be genetically and morphologically similar, and that only\&nbsp;an inferred 1-4\% of genetic differentiation among contemporary human populations can be attributed to genetic drift between stem populations. We show that model misspecification explains the variation in previous estimates of divergence times, and argue that studying a range of models is key to making robust inferences about deep history.</p>
},
	issn = {1476-4687},
	doi = {10.1038/s41586-023-06055-y},
	url = {https://www.nature.com/articles/s41586-023-06055-y},
	author = {Ragsdale, Aaron P and Weaver, Timothy D and Atkinson, Elizabeth G and Hoal, Eileen G and M{\"o}ller, Marlo and Henn, Brenna M and Gravel, Simon}
}
