@article {328994,
	title = {A comparative atlas of single-cell chromatin accessibility in the human brain.},
	journal = {Science},
	volume = {382},
	year = {2023},
	month = {2023 Oct 13},
	pages = {eadf7044},
	abstract = {<p>Recent advances in single-cell transcriptomics have illuminated the diverse neuronal and glial cell types within the human brain. However, the regulatory programs governing cell identity and function remain unclear. Using a single-nucleus assay for transposase-accessible chromatin using sequencing (snATAC-seq), we explored open chromatin landscapes across 1.1 million cells in 42 brain regions from three adults. Integrating this data unveiled 107 distinct cell types and their specific utilization of 544,735 candidate cis-regulatory DNA elements (cCREs) in the human genome. Nearly a third of the cCREs demonstrated conservation and chromatin accessibility in the mouse brain cells. We reveal strong links between specific brain cell types and neuropsychiatric disorders including schizophrenia, bipolar disorder, Alzheimer{\textquoteright}s disease (AD), and major depression, and have developed deep learning models to predict the regulatory roles of noncoding risk variants in these disorders.</p>
},
	issn = {1095-9203},
	doi = {10.1126/science.adf7044},
	url = {https://www.science.org/doi/10.1126/science.adf7044},
	author = {Li, Yang Eric and Preissl, Sebastian and Miller, Michael and Johnson, Nicholas D and Wang, Zihan and Jiao, Henry and Zhu, Chenxu and Wang, Zhaoning and Xie, Yang and Poirion, Olivier and Kern, Colin and Pinto-Duarte, Antonio and Tian, Wei and Siletti, Kimberly and Emerson, Nora and Osteen, Julia and Lucero, Jacinta and Lin, Lin and Yang, Qian and Zhu, Quan and Zemke, Nathan and Espinoza, Sarah and Yanny, Anna Marie and Nyhus, Julie and Dee, Nick and Casper, Tamara and Shapovalova, Nadiya and Hirschstein, Daniel and Hodge, Rebecca D and Linnarsson, Sten and Bakken, Trygve and Levi, Boaz and Keene, C Dirk and Shang, Jingbo and Lein, Ed and Wang, Allen and Behrens, M Margarita and Ecker, Joseph R and Ren, Bing}
}
