@article {329046,
	title = {Evolution of prefrontal cortex.},
	journal = {Neuropsychopharmacology},
	volume = {47},
	year = {2022},
	month = {2022 Jan},
	pages = {3-19},
	abstract = {<p>Subdivisions of the prefrontal cortex (PFC) evolved at different times. Agranular parts of the PFC emerged in early mammals, and rodents, primates, and other modern mammals share them by inheritance. These are limbic areas and include the agranular orbital cortex and agranular medial frontal cortex (areas 24, 32, and 25). Rodent research provides valuable insights into the structure, functions, and development of these shared areas, but it contributes less to parts of the PFC that are specific to primates, namely, the granular, isocortical PFC that dominates the frontal lobe in humans. The first granular PFC areas evolved either in early primates or in the last common ancestor of primates and tree shrews. Additional granular PFC areas emerged in the primate stem lineage, as represented by modern strepsirrhines. Other granular PFC areas evolved in simians, the group that includes apes, humans, and monkeys. In general, PFC accreted new areas along a roughly posterior to anterior trajectory during primate evolution. A major expansion of the granular PFC occurred in humans in concert with other association areas, with modifications of corticocortical connectivity and gene expression, although current evidence does not support the addition of a large number of new, human-specific PFC areas.</p>
},
	keywords = {Animals, Cerebral Cortex, Frontal Lobe, Prefrontal Cortex},
	issn = {1740-634X},
	doi = {10.1038/s41386-021-01076-5},
	author = {Preuss, Todd M and Wise, Steven P}
}
