@article {329051,
	title = {Genetics and geography of leukocyte telomere length in sub-Saharan Africans.},
	journal = {Hum Mol Genet},
	volume = {29},
	year = {2020},
	month = {2020 Nov 04},
	pages = {3014-3020},
	abstract = {<p>Leukocyte telomere length (LTL) might be causal in cardiovascular disease and major cancers. To elucidate the roles of genetics and geography in LTL variability across humans, we compared LTL measured in 1295 sub-Saharan Africans (SSAs) with 559 African-Americans (AAms) and 2464 European-Americans (EAms). LTL differed significantly across SSAs (P = 0.003), with the San from Botswana (with the oldest genomic ancestry) having the longest LTL and populations from Ethiopia having the shortest LTL. SSAs had significantly longer LTL than AAms [P = 6.5(e-16)] whose LTL was significantly longer than EAms [P = 2.5(e-7)]. Genetic variation in SSAs explained 52\% of LTL variance versus 27\% in AAms and 34\% in EAms. Adjustment for genetic variation removed the LTL differences among SSAs. LTL genetic variation among SSAs, with the longest LTL in the San, supports the hypothesis that longer LTL was ancestral in humans. Identifying factors driving LTL variation in Africa may have important ramifications for LTL-associated diseases.</p>
},
	keywords = {Adult, Africa South of the Sahara, Black or African American, Black People, Cardiovascular Diseases, Female, Humans, Leukocytes, Male, Middle Aged, Neoplasms, Phylogeography, Telomere, Telomere Homeostasis, White People},
	issn = {1460-2083},
	doi = {10.1093/hmg/ddaa187},
	author = {Hunt, Steven C and Hansen, Matthew E B and Verhulst, Simon and McQuillan, Michael A and Beggs, William and Lai, Tsung-Po and Mokone, Gaonyadiwe G and Mpoloka, Sununguko Wata and Meskel, Dawit Wolde and Belay, Gurja and Nyambo, Thomas B and Abnet, Christian C and Yeager, Meredith and Chanock, Stephen J and Province, Michael A and Williams, Scott M and Aviv, Abraham and Tishkoff, Sarah A}
}
