@article {330397,
	title = {Long genetic and social isolation in Neanderthals before their extinction},
	journal = {Cell Genomics},
	volume = {4},
	year = {2024},
	month = {2024/09/11/},
	pages = {100593},
	abstract = {<p>SummaryNeanderthal genomes have been recovered from sites across Eurasia, painting an increasingly complex picture of their populations\&rsquo; structure that mostly indicates that late European Neanderthals belonged to a single metapopulation with no significant evidence of population structure. Here, we report the discovery of a late Neanderthal individual, nicknamed \&ldquo;Thorin,\&rdquo; from Grotte Mandrin in Mediterranean France, and his genome. These dentognathic fossils, including a rare example of distomolars, are associated with a rich archeological record of Neanderthal final technological traditions in this region \&sim;50\&ndash;42 thousand years ago. Thorin\&rsquo;s genome reveals a relatively early divergence of \&sim;105 ka with other late Neanderthals. Thorin belonged to a population with a small group size that showed no genetic introgression with other known late European Neanderthals, revealing some 50 ka of genetic isolation of his lineage despite them living in neighboring regions. These results have important implications for resolving competing hypotheses about causes of the disappearance of the Neanderthals.</p>
},
	keywords = {Europe, Fossils, genetic and social isolation, genetic divergence, Genomics, last Neanderthals, Neanderthal extinction, population structure, Proteomics},
	isbn = {2666-979X},
	doi = {https://doi.org/10.1016/j.xgen.2024.100593},
	url = {https://www.sciencedirect.com/science/article/pii/S2666979X24001770},
	author = {Slimak, Ludovic and Vimala, Tharsika and Seguin-Orlando, Andaine and Metz, Laure and Zanolli, Cl{\'e}ment and Joannes-Boyau, Renaud and Frouin, Marine and Arnold, Lee J. and Demuro, Martina and Devi{\`e}se, Thibaut and Comeskey, Daniel and Buckley, Michael and Camus, Hubert and Muth, Xavier and Lewis, Jason E. and Bocherens, Herv{\'e} and Yvorra, Pascale and Tenailleau, Christophe and Duployer, Benjamin and Coqueugniot, H{\'e}l{\`e}ne and Dutour, Olivier and Higham, Thomas and Sikora, Martin}
}
