@article {330739,
	title = {Heterogeneous genetic architectures of prostate cancer susceptibility in sub-Saharan Africa.},
	journal = {Nat Genet},
	volume = {56},
	year = {2024},
	month = {2024 Oct},
	pages = {2093-2103},
	abstract = {<p>Men of African descent have the highest prostate cancer incidence and mortality rates, yet the genetic basis of prostate cancer in African men has been understudied. We used genomic data from 3,963 cases and 3,509 controls from Ghana, Nigeria, Senegal, South Africa and Uganda to infer ancestry-specific genetic architectures and fine-map disease associations. Fifteen independent associations at 8q24.21, 6q22.1 and 11q13.3 reached genome-wide significance, including four new associations. Intriguingly, multiple lead associations are private alleles, a pattern arising from recent mutations and the out-of-Africa bottleneck. These African-specific alleles contribute to haplotypes with odds ratios above 2.4. We found that the genetic architecture of prostate cancer differs across Africa, with effect size differences contributing more to this heterogeneity than allele frequency differences. Population genetic analyses reveal that African prostate cancer associations are largely governed by neutral evolution. Collectively, our findings emphasize the utility of conducting genetic studies that use diverse populations.</p>
},
	keywords = {Africa South of the Sahara, Alleles, Black People, Case-Control Studies, Gene Frequency, Genetic Predisposition to Disease, Genetics, Population, Genome-Wide Association Study, Haplotypes, Humans, Male, Polymorphism, Single Nucleotide, Prostatic Neoplasms},
	issn = {1546-1718},
	doi = {https://doi.org/10.1038/s41588-024-01931-3},
	url = {https://www.nature.com/articles/s41588-024-01931-3$\#$citeas},
	author = {Janivara, Rohini and Chen, Wenlong C and Hazra, Ujani and Baichoo, Shakuntala and Agalliu, Ilir and Kachambwa, Paidamoyo and Simonti, Corrine N and Brown, Lyda M and Tambe, Saanika P and Kim, Michelle S and Harlemon, Maxine and Jalloh, Mohamed and Muzondiwa, Dillon and Naidoo, Daphne and Ajayi, Olabode O and Snyper, Nana Yaa and Niang, Lamine and Diop, Halimatou and Ndoye, Medina and Mensah, James E and Abrahams, Afua O D and Biritwum, Richard and Adjei, Andrew A and Adebiyi, Akindele O and Shittu, Olayiwola and Ogunbiyi, Olufemi and Adebayo, Sikiru and Nwegbu, Maxwell M and Ajibola, Hafees O and Oluwole, Olabode P and Jamda, Mustapha A and Pentz, Audrey and Haiman, Christopher A and Spies, Petrus V and van der Merwe, Andr{\'e} and Cook, Michael B and Chanock, Stephen J and Berndt, Sonja I and Watya, Stephen and Lubwama, Alexander and Muchengeti, Mazvita and Doherty, Sean and Smyth, Natalie and Lounsbury, David and Fortier, Brian and Rohan, Thomas E and Jacobson, Judith S and Neugut, Alfred I and Hsing, Ann W and Gusev, Alexander and Aisuodionoe-Shadrach, Oseremen I and Joffe, Maureen and Adusei, Ben and Gueye, Serigne M and Fernandez, Pedro W and McBride, Jo and Andrews, Caroline and Petersen, Lindsay N and Lachance, Joseph and Rebbeck, Timothy R}
}
