@article {331038,
	title = {Local genetic adaptation to habitat in wild chimpanzees.},
	journal = {bioRxiv},
	year = {2024},
	month = {2024 Jul 09},
	abstract = {<p>How populations adapt to their environment is a fundamental question in biology. Yet we know surprisingly little about this process, especially for endangered species such as non-human great apes. Chimpanzees, our closest living relatives, are particularly interesting because they inhabit diverse habitats, from rainforest to woodland-savannah. Whether genetic adaptation facilitates such habitat diversity remains unknown, despite having wide implications for evolutionary biology and conservation. Using 828 newly generated exomes from wild chimpanzees, we find evidence of fine-scale genetic adaptation to habitat. Notably, adaptation to malaria in forest chimpanzees is mediated by the same genes underlying adaptation to malaria in humans. This work demonstrates the power of non-invasive samples to reveal genetic adaptations in endangered populations and highlights the importance of adaptive genetic diversity for chimpanzees.</p>
},
	issn = {2692-8205},
	doi = {10.1101/2024.07.09.601734},
	url = {https://www.science.org/doi/10.1126/science.adn7954},
	author = {Ostridge, Harrison J and Fontsere, Claudia and Lizano, Esther and Soto, Daniela C and Schmidt, Joshua M and Saxena, Vrishti and Alvarez-Estape, Marina and Barratt, Christopher D and Gratton, Paolo and Bocksberger, Ga{\"e}lle and Lester, Jack D and Dieguez, Paula and Agbor, Anthony and Angedakin, Samuel and Assumang, Alfred Kwabena and Bailey, Emma and Barubiyo, Donatienne and Bessone, Mattia and Brazzola, Gregory and Chancellor, Rebecca and Cohen, Heather and Coupland, Charlotte and Danquah, Emmanuel and Deschner, Tobias and Dotras, Laia and Dupain, Jef and Egbe, Villard Ebot and Granjon, Anne-C{\'e}line and Head, Josephine and Hedwig, Daniela and Hermans, Veerle and Hernandez-Aguilar, R Adriana and Jeffery, Kathryn J and Jones, Sorrel and Junker, Jessica and Kadam, Parag and Kaiser, Michael and Kalan, Ammie K and Kambere, Mbangi and Kienast, Ivonne and Kujirakwinja, Deo and Langergraber, Kevin E and Lapuente, Juan and Larson, Bradley and Laudisoit, Anne and Lee, Kevin C and Llana, Manuel and Maretti, Giovanna and Martin, Rumen and Meier, Amelia and Morgan, David and Neil, Emily and Nicholl, Sonia and Nixon, Stuart and Normand, Emmanuelle and Orbell, Christopher and Ormsby, Lucy Jayne and Orume, Robinson and Pacheco, Liliana and Preece, Jodie and Regnaut, Sebastien and Robbins, Martha M and Rundus, Aaron and Sanz, Crickette and Sciaky, Lilah and Sommer, Volker and Stewart, Fiona A and Tagg, Nikki and T{\'e}donzong, Luc Roscelin and van Schijndel, Joost and Vendras, Elleni and Wessling, Erin G and Willie, Jacob and Wittig, Roman M and Yuh, Yisa Ginath and Yurkiw, Kyle and Vigilant, Linda and Piel, Alex and Boesch, Christophe and K{\"u}hl, Hjalmar S and Dennis, Megan Y and Marques-Bonet, Tomas and Arandjelovic, Mimi and Andr{\'e}s, Aida M}
}
