@article {331626,
	title = {A male Denisovan mandible from Pleistocene Taiwan},
	journal = {Science},
	volume = {388},
	year = {2025},
	note = {<p>doi: 10.1126/science.ads3888</p>
},
	month = {2025/04/11},
	pages = {176 - 180},
	abstract = {<p>Denisovans are an extinct hominin group defined by ancient genomes of Middle to Late Pleistocene fossils from southern Siberia. Although genomic evidence suggests their widespread distribution throughout eastern Asia and possibly Oceania, so far only a few fossils from the Altai and Tibet are confidently identified molecularly as Denisovan. We identified a hominin mandible (Penghu 1) from Taiwan (10,000 to 70,000 years ago or 130,000 to 190,000 years ago) as belonging to a male Denisovan by applying ancient protein analysis. We retrieved 4241 amino acid residues and identified two Denisovan-specific variants. The increased fossil sample of Denisovans demonstrates their wider distribution, including warm and humid regions, as well as their shared distinct robust dentognathic traits that markedly contrast with their sister group, Neanderthals. Denisovans are a Pleistocene hominin lineage first identified genomically and known from only a few fossils. Although genomic studies suggest that they were widespread throughout Asia, fossils of this group have thus far only been identified from regions with cold climates, Siberia and Tibet. Tsutaya et al. used ancient proteomic analysis on a previously unidentified hominin mandible from Taiwan and identified it as having belonged to a male Denisovan. This identification confirms previous genomic predictions of the group?s widespread occurrence, including in warmer climates. The robust nature of this mandible is similar to that seen in a Denisovan one from Tibet, suggesting that this is a consistent trait for the lineage. ?Sacha VignieriDenisovans are an extinct hominin group defined by ancient genomes of Middle to Late Pleistocene fossils from southern Siberia. Although genomic evidence suggests their widespread distribution throughout eastern Asia and possibly Oceania, so far only a few fossils from the Altai and Tibet are confidently identified molecularly as Denisovan. We identified a hominin mandible (Penghu 1) from Taiwan (10,000 to 70,000 years ago or 130,000 to 190,000 years ago) as belonging to a male Denisovan by applying ancient protein analysis. We retrieved 4241 amino acid residues and identified two Denisovan-specific variants. The increased fossil sample of Denisovans demonstrates their wider distribution, including warm and humid regions, as well as their shared distinct robust dentognathic traits that markedly contrast with their sister group, Neanderthals. Denisovans are a Pleistocene hominin lineage first identified genomically and known from only a few fossils. Although genomic studies suggest that they were widespread throughout Asia, fossils of this group have thus far only been identified from regions with cold climates, Siberia and Tibet. Tsutaya et al. used ancient proteomic analysis on a previously unidentified hominin mandible from Taiwan and identified it as having belonged to a male Denisovan. This identification confirms previous genomic predictions of the group?s widespread occurrence, including in warmer climates. The robust nature of this mandible is similar to that seen in a Denisovan one from Tibet, suggesting that this is a consistent trait for the lineage. ?Sacha Vignieri</p>
},
	doi = {https://doi.org/10.1126/science.ads3888},
	url = {https://www.science.org/doi/10.1126/science.ads3888},
	author = {Tsutaya, Takumi and Sawafuji, Rikai and Taurozzi, Alberto J. and Fagern{\"a}s, Zandra and Patramanis, Ioannis and Troch{\'e}, Gaudry and Mackie, Meaghan and Gakuhari, Takashi and Oota, Hiroki and Tsai, Cheng-Hsiu and Olsen, Jesper V. and Kaifu, Yousuke and Chang, Chun-Hsiang and Cappellini, Enrico and Welker, Frido}
}
