<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Padler-Karavani, V.</style></author><author><style face="normal" font="default" size="100%">Hurtado-Ziola, N.</style></author><author><style face="normal" font="default" size="100%">Pu, M.</style></author><author><style face="normal" font="default" size="100%">Yu, H.</style></author><author><style face="normal" font="default" size="100%">Huang, S.</style></author><author><style face="normal" font="default" size="100%">Muthana, S.</style></author><author><style face="normal" font="default" size="100%">Chokhawala, H. A.</style></author><author><style face="normal" font="default" size="100%">Cao, H.</style></author><author><style face="normal" font="default" size="100%">Secrest, P.</style></author><author><style face="normal" font="default" size="100%">Friedmann-Morvinski, D.</style></author><author><style face="normal" font="default" size="100%">Singer, O.</style></author><author><style face="normal" font="default" size="100%">Ghaderi, D.</style></author><author><style face="normal" font="default" size="100%">Verma, I. M.</style></author><author><style face="normal" font="default" size="100%">Liu, Y. T.</style></author><author><style face="normal" font="default" size="100%">Messer, K.</style></author><author><style face="normal" font="default" size="100%">Chen, X.</style></author><author><style face="normal" font="default" size="100%">Ajit Varki</style></author><author><style face="normal" font="default" size="100%">Schwab, R.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Human xeno-autoantibodies against a non-human sialic acid serve as novel serum biomarkers and immunotherapeutics in cancer</style></title><secondary-title><style face="normal" font="default" size="100%">Cancer Res</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Cancer research</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Adenocarcinoma/blood/immunology/therapy</style></keyword><keyword><style  face="normal" font="default" size="100%">Animals</style></keyword><keyword><style  face="normal" font="default" size="100%">Autoantibodies/*blood/immunology/*pharmacology</style></keyword><keyword><style  face="normal" font="default" size="100%">Breast Neoplasms/blood/immunology/therapy</style></keyword><keyword><style  face="normal" font="default" size="100%">Colonic Neoplasms/blood/immunology/therapy</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Immunization</style></keyword><keyword><style  face="normal" font="default" size="100%">Immunoglobulin G/immunology/is</style></keyword><keyword><style  face="normal" font="default" size="100%">Passive/*methods</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2011</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 1</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/21505105</style></url></web-urls></urls><number><style face="normal" font="default" size="100%">9</style></number><edition><style face="normal" font="default" size="100%">2011/04/21</style></edition><volume><style face="normal" font="default" size="100%">71</style></volume><pages><style face="normal" font="default" size="100%">3352-63</style></pages><isbn><style face="normal" font="default" size="100%">1538-7445 (Electronic)00</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Human carcinomas can metabolically incorporate and present the dietary non-human sialic acid Neu5Gc, which differs from the human sialic acid N-acetylneuraminic acid (Neu5Ac) by 1 oxygen atom. Tumor-associated Neu5Gc can interact with low levels of circulating anti-Neu5Gc antibodies, thereby facilitating tumor progression via chronic inflammation in a human-like Neu5Gc-deficient mouse model. Here we show that human anti-Neu5Gc antibodies can be affinity-purified in substantial amounts from clinically approved intravenous IgG (IVIG) and used at higher concentrations to suppress growth of the same Neu5Gc-expressing tumors. Hypothesizing that this polyclonal spectrum of human anti-Neu5Gc antibodies also includes potential cancer biomarkers, we then characterize them in cancer and noncancer patients&#039; sera, using a novel sialoglycan microarray presenting multiple Neu5Gc-glycans and control Neu5Ac-glycans. Antibodies against Neu5Gcalpha2-6GalNAcalpha1-O-Ser/Thr (GcSTn) were found to be more prominent in patients with carcinomas than with other diseases. This unusual epitope arises from dietary Neu5Gc incorporation into the carcinoma marker Sialyl-Tn, and is the first example of such a novel mechanism for biomarker generation. Finally, human serum or purified antibodies rich in anti-GcSTn-reactivity kill GcSTn-expressing human tumors via complement-dependent cytotoxicity or antibody-dependent cellular cytotoxicity. Such xeno-autoantibodies and xeno-autoantigens have potential for novel diagnostics, prognostics, and therapeutics in human carcinomas.&lt;/p&gt;</style></abstract><work-type><style face="normal" font="default" size="100%">Research Support, N.I.H., Extramural</style></work-type><accession-num><style face="normal" font="default" size="100%"> </style></accession-num><notes><style face="normal" font="default" size="100%">&lt;p&gt;&lt;span role=&quot;menubar&quot;&gt;Cancer Res.&lt;/span&gt;&amp;nbsp;2011 May 1;71(9):3352-63. doi: 10.1158/0008-5472.CAN-10-4102. Epub 2011 Apr 19.&amp;nbsp;&lt;/p&gt;</style></notes><custom2><style face="normal" font="default" size="100%">3085609</style></custom2><auth-address><style face="normal" font="default" size="100%">University of California at San Diego, CA, USA.</style></auth-address></record></records></xml>