<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ajit Varki</style></author><author><style face="normal" font="default" size="100%">Geschwind, D. H.</style></author><author><style face="normal" font="default" size="100%">Eichler, E. E.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Explaining human uniqueness: genome interactions with environment, behaviour and culture</style></title><secondary-title><style face="normal" font="default" size="100%">Nat Rev Genet</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Nature reviews. Genetics</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">*Culture</style></keyword><keyword><style  face="normal" font="default" size="100%">*Environment</style></keyword><keyword><style  face="normal" font="default" size="100%">*Genetic Speciation</style></keyword><keyword><style  face="normal" font="default" size="100%">*Individuality</style></keyword><keyword><style  face="normal" font="default" size="100%">Animals</style></keyword><keyword><style  face="normal" font="default" size="100%">Behavior/*physiology</style></keyword><keyword><style  face="normal" font="default" size="100%">Biological</style></keyword><keyword><style  face="normal" font="default" size="100%">Chromosomes</style></keyword><keyword><style  face="normal" font="default" size="100%">Evolution</style></keyword><keyword><style  face="normal" font="default" size="100%">Gene Regulatory Networks/physiology</style></keyword><keyword><style  face="normal" font="default" size="100%">Genetic Variation/physiology</style></keyword><keyword><style  face="normal" font="default" size="100%">Genome</style></keyword><keyword><style  face="normal" font="default" size="100%">Human</style></keyword><keyword><style  face="normal" font="default" size="100%">Human/*physiology</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Models</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2008</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Oct</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/18802414</style></url></web-urls></urls><number><style face="normal" font="default" size="100%">10</style></number><edition><style face="normal" font="default" size="100%">2008/09/20</style></edition><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">749-63</style></pages><isbn><style face="normal" font="default" size="100%">1471-0064 (Electronic)14</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;What makes us human? Specialists in each discipline respond through the lens of their own expertise. In fact, &#039;anthropogeny&#039; (explaining the origin of humans) requires a transdisciplinary approach that eschews such barriers. Here we take a genomic and genetic perspective towards molecular variation, explore systems analysis of gene expression and discuss an organ-systems approach. Rejecting any &#039;genes versus environment&#039; dichotomy, we then consider genome interactions with environment, behaviour and culture, finally speculating that aspects of human uniqueness arose because of a primate evolutionary trend towards increasing and irreversible dependence on learned behaviours and culture - perhaps relaxing allowable thresholds for large-scale genomic diversity.&lt;/p&gt;</style></abstract><work-type><style face="normal" font="default" size="100%">Comparative StudyResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov&#039;tReview</style></work-type><accession-num><style face="normal" font="default" size="100%">18802414 PMID</style></accession-num><notes><style face="normal" font="default" size="100%">&lt;p&gt;Nat Rev Genet. 2008 Oct;9(10):749-63.&lt;/p&gt;&lt;p&gt;&amp;nbsp;&lt;/p&gt;</style></notes><custom2><style face="normal" font="default" size="100%">2756412</style></custom2><auth-address><style face="normal" font="default" size="100%">Center for Academic Research and Training in Anthropogeny, University of California, San Diego, La Jolla, California 92093, USA. a1varki@ucsd.edu</style></auth-address></record></records></xml>