<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Garcia-Perez, J. L.</style></author><author><style face="normal" font="default" size="100%">Marchetto, M. C.</style></author><author><style face="normal" font="default" size="100%">Muotri, A. R.</style></author><author><style face="normal" font="default" size="100%">Coufal, N. G.</style></author><author><style face="normal" font="default" size="100%">Gage, F. H.</style></author><author><style face="normal" font="default" size="100%">O&#039;Shea, K. S.</style></author><author><style face="normal" font="default" size="100%">Moran, J. V.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">LINE-1 retrotransposition in human embryonic stem cells</style></title><secondary-title><style face="normal" font="default" size="100%">Hum Mol Genet</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Human molecular genetics</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cell Differentiation</style></keyword><keyword><style  face="normal" font="default" size="100%">Cell Line</style></keyword><keyword><style  face="normal" font="default" size="100%">DNA/metabolism</style></keyword><keyword><style  face="normal" font="default" size="100%">Embryonic Stem Cells/*metabolism</style></keyword><keyword><style  face="normal" font="default" size="100%">Evolution</style></keyword><keyword><style  face="normal" font="default" size="100%">Genetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Genome</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Long Interspersed Nucleotide Elements/*genetics</style></keyword><keyword><style  face="normal" font="default" size="100%">Microscopy</style></keyword><keyword><style  face="normal" font="default" size="100%">Models</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular</style></keyword><keyword><style  face="normal" font="default" size="100%">P</style></keyword><keyword><style  face="normal" font="default" size="100%">Phase-Contrast</style></keyword><keyword><style  face="normal" font="default" size="100%">Plasmids/metabolism</style></keyword><keyword><style  face="normal" font="default" size="100%">Tumor</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2007</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Jul 1</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/17468180</style></url></web-urls></urls><number><style face="normal" font="default" size="100%">13</style></number><edition><style face="normal" font="default" size="100%">2007/05/01</style></edition><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1569-77</style></pages><isbn><style face="normal" font="default" size="100%">0964-6906 (Print)0964-69</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;LINE-1 elements comprise approximately 17% of human DNA and their mobility continues to impact genome evolution. However, little is known about the types of non-transformed cells that can support LINE-1 retrotransposition. Here, we show that human embryonic stem cells express endogenous LINE-1 elements and can accommodate LINE-1 retrotransposition in vitro. The resultant retrotransposition events can occur into genes and can result in the concomitant deletion of genomic DNA at the target site. Thus, these data suggest that LINE-1 retrotransposition events may occur during early stages of human development.&lt;/p&gt;</style></abstract><work-type><style face="normal" font="default" size="100%">Research Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov&#039;t</style></work-type><accession-num><style face="normal" font="default" size="100%">17468180</style></accession-num><notes><style face="normal" font="default" size="100%">&lt;p&gt;Hum Mol Genet. 2007 Jul 1;16(13):1569-77. Epub 2007 Apr 27&lt;/p&gt;</style></notes><auth-address><style face="normal" font="default" size="100%">Departments of Human Genetics and Internal Medicine, University of Michigan Medical School, 1241 E. Catherine Street, Ann Arbor, MI 48109, USA.</style></auth-address></record></records></xml>