<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Muotri, A. R.</style></author><author><style face="normal" font="default" size="100%">Chu, V. T.</style></author><author><style face="normal" font="default" size="100%">Marchetto, M. C.</style></author><author><style face="normal" font="default" size="100%">Deng, W.</style></author><author><style face="normal" font="default" size="100%">Moran, J. V.</style></author><author><style face="normal" font="default" size="100%">Gage, F. H.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Somatic mosaicism in neuronal precursor cells mediated by L1 retrotransposition</style></title><secondary-title><style face="normal" font="default" size="100%">Nature</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Nature</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Animals</style></keyword><keyword><style  face="normal" font="default" size="100%">Brain/cytology/metabolism</style></keyword><keyword><style  face="normal" font="default" size="100%">Cell Differentiation</style></keyword><keyword><style  face="normal" font="default" size="100%">Cell Lineage</style></keyword><keyword><style  face="normal" font="default" size="100%">Cells</style></keyword><keyword><style  face="normal" font="default" size="100%">Cultured</style></keyword><keyword><style  face="normal" font="default" size="100%">DNA-Binding Proteins/genetics</style></keyword><keyword><style  face="normal" font="default" size="100%">Gene Expression Regulation</style></keyword><keyword><style  face="normal" font="default" size="100%">Green Fluorescent Proteins/genetics/metabolism</style></keyword><keyword><style  face="normal" font="default" size="100%">HMGB Proteins/genetics</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Long Interspersed Nucleotid</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2005</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Jun 16</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/15959507</style></url></web-urls></urls><number><style face="normal" font="default" size="100%">7044</style></number><edition><style face="normal" font="default" size="100%">2005/06/17</style></edition><volume><style face="normal" font="default" size="100%">435</style></volume><pages><style face="normal" font="default" size="100%">903-10</style></pages><isbn><style face="normal" font="default" size="100%">1476-4687 (Electronic)00</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Revealing the mechanisms for neuronal somatic diversification remains a central challenge for understanding individual differences in brain organization and function. Here we show that an engineered human LINE-1 (for long interspersed nuclear element-1; also known as L1) element can retrotranspose in neuronal precursors derived from rat hippocampus neural stem cells. The resulting retrotransposition events can alter the expression of neuronal genes, which, in turn, can influence neuronal cell fate in vitro. We further show that retrotransposition of a human L1 in transgenic mice results in neuronal somatic mosaicism. The molecular mechanism of action is probably mediated through Sox2, because a decrease in Sox2 expression during the early stages of neuronal differentiation is correlated with increases in both L1 transcription and retrotransposition. Our data therefore indicate that neuronal genomes might not be static, but some might be mosaic because of de novo L1 retrotransposition events.&lt;/p&gt;
</style></abstract><work-type><style face="normal" font="default" size="100%">Research Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov&#039;tResearch Support, U.S. Gov&#039;t, P.H.S.</style></work-type><accession-num><style face="normal" font="default" size="100%">15959507</style></accession-num><notes><style face="normal" font="default" size="100%">&lt;p&gt;EnglandNature. 2005 Jun 16;435(7044):903-10.&lt;/p&gt;
</style></notes><auth-address><style face="normal" font="default" size="100%">Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA.</style></auth-address></record></records></xml>