<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Wildman, D. E.</style></author><author><style face="normal" font="default" size="100%">Chen, C.</style></author><author><style face="normal" font="default" size="100%">Erez, O.</style></author><author><style face="normal" font="default" size="100%">Grossman, L. I.</style></author><author><style face="normal" font="default" size="100%">Goodman, M.</style></author><author><style face="normal" font="default" size="100%">Romero, R.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evolution of the mammalian placenta revealed by phylogenetic analysis</style></title><secondary-title><style face="normal" font="default" size="100%">Proc Natl Acad Sci U S A</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Proceedings of the National Academy of Sciences of the United States of America</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">&amp;</style></keyword><keyword><style  face="normal" font="default" size="100%">*Phylogeny</style></keyword><keyword><style  face="normal" font="default" size="100%">Animals</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">histology/*physiology</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Mammals/*classification/*genetics/physiology</style></keyword><keyword><style  face="normal" font="default" size="100%">Maternal-Fetal Exchange</style></keyword><keyword><style  face="normal" font="default" size="100%">Placenta/anatomy</style></keyword><keyword><style  face="normal" font="default" size="100%">Pregnancy</style></keyword><keyword><style  face="normal" font="default" size="100%">Primates/physiology</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2006</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Feb 28</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/16492730</style></url></web-urls></urls><number><style face="normal" font="default" size="100%">9</style></number><edition><style face="normal" font="default" size="100%">2006/02/24</style></edition><volume><style face="normal" font="default" size="100%">103</style></volume><pages><style face="normal" font="default" size="100%">3203-8</style></pages><isbn><style face="normal" font="default" size="100%">0027-8424 (Print)0027-84</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;The placenta is essential for the success of therian mammalian reproduction. Intense selective pressure has shaped changes in placental anatomy and function during mammalian cladogenesis. Here we challenge the view that the hemochorial placenta is a derived feature in haplorhine primates. Using phylogenetic and statistical analyses of molecular and morphological data, we demonstrate that the ancestral eutherian mammalian placenta had the distinctive features of (i) hemochorial placental interface, (ii) a discoid shape, and (iii) a labyrinthine maternofetal interdigitation. These results reveal that the first eutherians had a deeply invasive placenta and imply that the major role of the placenta in sustaining pregnancy and promoting gestational development existed throughout the eutherian lineage that descended to humans from the last common ancestor of placental mammals. The ancestral state reconstructions demonstrate both clade-specific patterns of placentation and specific cases of convergent evolution within individual eutherian clades. Determining the mammalian pattern of change in placental morphology is important for understanding the evolutionary pressures faced by these lineages. The effects of selection pressures on the efficiency of placentation may stem from changes in nutritional demand, gestational length, number of embryos per pregnancy, uterine shape, and maternal body constitution. The influence of these factors on placental development needs further investigation.&lt;/p&gt;</style></abstract><work-type><style face="normal" font="default" size="100%">Research Support, N.I.H., Intramural</style></work-type><accession-num><style face="normal" font="default" size="100%">16492730</style></accession-num><notes><style face="normal" font="default" size="100%">&lt;p&gt;Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3203-8. Epub 2006 Feb 21.&lt;/p&gt;</style></notes><custom2><style face="normal" font="default" size="100%">1413940</style></custom2><auth-address><style face="normal" font="default" size="100%">Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.</style></auth-address></record></records></xml>