<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Thompson, P. M.</style></author><author><style face="normal" font="default" size="100%">Lee, A. D.</style></author><author><style face="normal" font="default" size="100%">Dutton, R. A.</style></author><author><style face="normal" font="default" size="100%">Geaga, J. A.</style></author><author><style face="normal" font="default" size="100%">Hayashi, K. M.</style></author><author><style face="normal" font="default" size="100%">Eckert, M. A.</style></author><author><style face="normal" font="default" size="100%">Bellugi, U.</style></author><author><style face="normal" font="default" size="100%">Galaburda, A. M.</style></author><author><style face="normal" font="default" size="100%">Korenberg, J. R.</style></author><author><style face="normal" font="default" size="100%">Mills, D. L.</style></author><author><style face="normal" font="default" size="100%">Toga, A. W.</style></author><author><style face="normal" font="default" size="100%">Reiss, A. L.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Abnormal cortical complexity and thickness profiles mapped in Williams syndrome</style></title><secondary-title><style face="normal" font="default" size="100%">J Neurosci</style></secondary-title><alt-title><style face="normal" font="default" size="100%">The Journal of neuroscience : the official journal of the Society for Neuroscience</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">*Brain Mapping</style></keyword><keyword><style  face="normal" font="default" size="100%">Adolescent</style></keyword><keyword><style  face="normal" font="default" size="100%">Adult</style></keyword><keyword><style  face="normal" font="default" size="100%">Age Factors</style></keyword><keyword><style  face="normal" font="default" size="100%">Case-Control Studies</style></keyword><keyword><style  face="normal" font="default" size="100%">Cerebral Cortex/*abnormalities/*pathology</style></keyword><keyword><style  face="normal" font="default" size="100%">Child</style></keyword><keyword><style  face="normal" font="default" size="100%">Computer-Assisted/methods</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Functional Laterality</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Image Processing</style></keyword><keyword><style  face="normal" font="default" size="100%">Imaging</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">Middle Ag</style></keyword><keyword><style  face="normal" font="default" size="100%">Three-Dimensional/methods</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2005</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Apr 20</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/15843618</style></url></web-urls></urls><number><style face="normal" font="default" size="100%">16</style></number><edition><style face="normal" font="default" size="100%">2005/04/22</style></edition><volume><style face="normal" font="default" size="100%">25</style></volume><pages><style face="normal" font="default" size="100%">4146-58</style></pages><isbn><style face="normal" font="default" size="100%">1529-2401 (Electronic)02</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;We identified and mapped an anatomically localized failure of cortical maturation in Williams syndrome (WS), a genetic condition associated with deletion of approximately 20 contiguous genes on chromosome 7. Detailed three-dimensional (3D) maps of cortical thickness, based on magnetic resonance imaging (MRI) scans of 164 brain hemispheres, identified a delimited zone of right hemisphere perisylvian cortex that was thicker in WS than in matched controls, despite pervasive gray and white matter deficits and reduced total cerebral volumes. 3D cortical surface models were extracted from 82 T1-weighted brain MRI scans (256 x 192 x 124 volumes) of 42 subjects with genetically confirmed WS (mean +/- SD, 29.2 +/- 9.0 years of age; 19 males, 23 females) and 40 age-matched healthy controls (27.5 +/- 7.4 years of age; 16 males, 24 females). A cortical pattern-matching technique used 72 sulcal landmarks traced on each brain as anchors to align cortical thickness maps across subjects, build group average maps, and identify regions with altered cortical thickness in WS. Cortical models were remeshed in frequency space to compute their fractal dimension (surface complexity) for each hemisphere and lobe. Surface complexity was significantly increased in WS (p &amp;lt; 0.0015 and p &amp;lt; 0.0014 for left and right hemispheres, respectively) and correlated with temporoparietal gyrification differences, classified via Steinmetz criteria. In WS, cortical thickness was increased by 5-10% in a circumscribed right hemisphere perisylvian and inferior temporal zone (p &amp;lt; 0.002). Spatially extended cortical regions were identified with increased complexity and thickness; cortical thickness and complexity were also positively correlated in controls (p &amp;lt; 0.03). These findings visualize cortical zones with altered anatomy in WS, which merit additional study with techniques to assess function and connectivity.&lt;/p&gt;</style></abstract><work-type><style face="normal" font="default" size="100%">Comparative StudyResearch Support, N.I.H., ExtramuralResearch Support, U.S. Gov&#039;t, P.H.S.</style></work-type><accession-num><style face="normal" font="default" size="100%">15843618</style></accession-num><notes><style face="normal" font="default" size="100%">&lt;p&gt;J Neurosci. 2005 Apr 20;25(16):4146-58.&lt;/p&gt;</style></notes><auth-address><style face="normal" font="default" size="100%">Laboratory of Neuroimaging, Brain Mapping Division, Department of Neurology, University of California Los Angeles School of Medicine, Los Angeles, California 90095-1769, USA. thompson@loni.ucla.edu &lt;thompson@loni.ucla.edu&gt;</style></auth-address></record></records></xml>