<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Baker, M.E.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The microbiome as a target for endocrine disruptors: Novel chemicals may disrupt androgen and microbiome-mediated autoimmunity</style></title><secondary-title><style face="normal" font="default" size="100%">Endocrine Disruptors</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">12/2014</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.tandfonline.com/doi/pdf/10.4161/23273739.2014.964539 </style></url></web-urls></urls><number><style face="normal" font="default" size="100%">1</style></number><pages><style face="normal" font="default" size="100%">e964539</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;In non-obese diabetic (NOD) mice, there is a sex-biased increase in female incidence of type 1 diabetes. Recently, the microbiome was found to protect male mice from type 1 diabetes. Transfer of microbiota from adult NOD male mice to pre-pubertal female mice protects against later incidence of sex-biased type 1 diabetes. This protection involves, in part, microbiome-mediated increased tes- tosterone synthesis, which up-regulates the interleukin and interferon pathways. The microbiome-derived signals that mediate this response are unknown, although due to the diversity of chemicals synthesized in the microbiome some are likely to have structures unlike andro- gens. This suggests that novel synthetic and/or plant-derived chemicals may affect sex-biased autoimmune diseases through disruption of protective signal- ing networks between the microbiome and its host.&lt;/p&gt;</style></abstract></record></records></xml>