<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Schwarz, F</style></author><author><style face="normal" font="default" size="100%">Pearce, OM</style></author><author><style face="normal" font="default" size="100%">Wang, X</style></author><author><style face="normal" font="default" size="100%">Samraj, AN</style></author><author><style face="normal" font="default" size="100%">Laubli, H</style></author><author><style face="normal" font="default" size="100%">Garcia, JO</style></author><author><style face="normal" font="default" size="100%">Lin, H</style></author><author><style face="normal" font="default" size="100%">Fu, X</style></author><author><style face="normal" font="default" size="100%">Garcia-Bingman, A</style></author><author><style face="normal" font="default" size="100%">Secrest, P</style></author><author><style face="normal" font="default" size="100%">Romanoski, CE</style></author><author><style face="normal" font="default" size="100%">Heyser, C</style></author><author><style face="normal" font="default" size="100%">Glass, CK</style></author><author><style face="normal" font="default" size="100%">Hazen, SL</style></author><author><style face="normal" font="default" size="100%">Nissi M Varki</style></author><author><style face="normal" font="default" size="100%">Ajit Varki</style></author><author><style face="normal" font="default" size="100%">Gagneux, P</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Siglec receptors impact mammalian lifespan by modulating oxidative stress.</style></title><secondary-title><style face="normal" font="default" size="100%">Elife</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2015</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/25846707</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">4</style></volume><isbn><style face="normal" font="default" size="100%">2050-084X</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Aging is a multifactorial process that includes the lifelong accumulation of molecular damage, leading to age-related frailty, disability and disease, and eventually death. In this study, we report evidence of a significant correlation between the number of genes encoding the immunomodulatory CD33-related sialic acid-binding immunoglobulin-like receptors (CD33rSiglecs) and maximum lifespan in mammals. In keeping with this, we show that mice lacking Siglec-E, the main member of the CD33rSiglec family, exhibit reduced survival. Removal of Siglec-E causes the development of exaggerated signs of aging at the molecular, structural, and cognitive level. We found that accelerated aging was related both to an unbalanced ROS metabolism, and to a secondary impairment in detoxification of reactive molecules, ultimately leading to increased damage to cellular DNA, proteins, and lipids. Taken together, our data suggest that CD33rSiglecs co-evolved in mammals to achieve a better management of oxidative stress during inflammation, which in turn reduces molecular damage and extends lifespan.&lt;/p&gt;
</style></abstract><accession-num><style face="normal" font="default" size="100%">25846707</style></accession-num></record></records></xml>