<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Baker, M. E.</style></author><author><style face="normal" font="default" size="100%">Asnaashari, P.</style></author><author><style face="normal" font="default" size="100%">Chang, D. J.</style></author><author><style face="normal" font="default" size="100%">McDonnell, S.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">3D models of lamprey progesterone receptor complexed with progesterone, 7alpha-hydroxy-progesterone and 15alpha-hydroxy-progesterone</style></title><secondary-title><style face="normal" font="default" size="100%">Steroids</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Steroids</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">&amp;</style></keyword><keyword><style  face="normal" font="default" size="100%">Amino Acid Sequence</style></keyword><keyword><style  face="normal" font="default" size="100%">Animals</style></keyword><keyword><style  face="normal" font="default" size="100%">derivatives/ chemistry</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Lampreys</style></keyword><keyword><style  face="normal" font="default" size="100%">Models</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular Sequence Data</style></keyword><keyword><style  face="normal" font="default" size="100%">Progesterone/ analogs</style></keyword><keyword><style  face="normal" font="default" size="100%">Progesterone/ chemistry</style></keyword><keyword><style  face="normal" font="default" size="100%">Receptors</style></keyword><keyword><style  face="normal" font="default" size="100%">Sequence Alignment</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2011</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Jan</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">1-2</style></number><edition><style face="normal" font="default" size="100%">2010/11/09</style></edition><volume><style face="normal" font="default" size="100%">76</style></volume><pages><style face="normal" font="default" size="100%">169-76</style></pages><isbn><style face="normal" font="default" size="100%">1878-5867 (Electronic)00</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Sea lamprey, a basal vertebrate, contains a progesterone receptor [PR]. An unusual property of lamprey is that gonadotropin-releasing hormone induces synthesis of 15alpha-hydroxy-progesterone [15alpha-OH-P] instead of progesterone. There also is indirect evidence for 7alpha-OH-P in lamprey serum. To determine if there is a structural basis for the binding of 7alpha-OH-P and 15alpha-OH-P to lamprey PR, we constructed 3D models of the lamprey PR complexed with progesterone, 7alpha-OH-P and 15alpha-OH-P. These 3D models reveal that Met-277 in lamprey PR has a specific interaction with the 15alpha-hydroxyl on 15alpha-OH-P and with Met-192, which also contacts the 15alpha-hydroxyl group. We also find that 7alpha-OH-P has favorable contacts with side-chains in lamprey PR. BLAST searches reveal that Met-277 on lamprey PR is unique among vertebrate PRs. This unique site on lamprey PR could be a target for compounds to control reproduction in sea lamprey, an environmental pest in Lake Michigan.&lt;/p&gt;</style></abstract><notes><style face="normal" font="default" size="100%">&lt;p&gt;Steroids. 2011 Jan;76(1-2):169-76. doi: 10.1016/j.steroids.2010.10.008. Epub 2010 Nov 3.&lt;/p&gt;</style></notes></record></records></xml>