<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Lister, R.</style></author><author><style face="normal" font="default" size="100%">Mukamel, E. A.</style></author><author><style face="normal" font="default" size="100%">Nery, J. R.</style></author><author><style face="normal" font="default" size="100%">Urich, M.</style></author><author><style face="normal" font="default" size="100%">Puddifoot, C. A.</style></author><author><style face="normal" font="default" size="100%">Johnson, N. D.</style></author><author><style face="normal" font="default" size="100%">Lucero, J.</style></author><author><style face="normal" font="default" size="100%">Huang, Y.</style></author><author><style face="normal" font="default" size="100%">Dwork, A. J.</style></author><author><style face="normal" font="default" size="100%">Schultz, M. D.</style></author><author><style face="normal" font="default" size="100%">Yu, M.</style></author><author><style face="normal" font="default" size="100%">Tonti-Filippini, J.</style></author><author><style face="normal" font="default" size="100%">Heyn, H.</style></author><author><style face="normal" font="default" size="100%">Hu, S.</style></author><author><style face="normal" font="default" size="100%">Wu, J. C.</style></author><author><style face="normal" font="default" size="100%">Rao, A.</style></author><author><style face="normal" font="default" size="100%">Esteller, M.</style></author><author><style face="normal" font="default" size="100%">He, C.</style></author><author><style face="normal" font="default" size="100%">Haghighi, F. G.</style></author><author><style face="normal" font="default" size="100%">Sejnowski, T. J.</style></author><author><style face="normal" font="default" size="100%">Behrens, M. M.</style></author><author><style face="normal" font="default" size="100%">Ecker, J. R.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Global epigenomic reconfiguration during mammalian brain development</style></title><secondary-title><style face="normal" font="default" size="100%">Science</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">&amp;</style></keyword><keyword><style  face="normal" font="default" size="100%">*DNA Methylation</style></keyword><keyword><style  face="normal" font="default" size="100%">*Epigenesis</style></keyword><keyword><style  face="normal" font="default" size="100%">*Gene Expression Regulation</style></keyword><keyword><style  face="normal" font="default" size="100%">5-Methylcytosine/metabolism</style></keyword><keyword><style  face="normal" font="default" size="100%">Adult</style></keyword><keyword><style  face="normal" font="default" size="100%">Animals</style></keyword><keyword><style  face="normal" font="default" size="100%">Base Sequence</style></keyword><keyword><style  face="normal" font="default" size="100%">Conserved Sequence</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytosine/*analogs</style></keyword><keyword><style  face="normal" font="default" size="100%">derivatives/metabolism</style></keyword><keyword><style  face="normal" font="default" size="100%">Devel</style></keyword><keyword><style  face="normal" font="default" size="100%">development</style></keyword><keyword><style  face="normal" font="default" size="100%">Epigenomics</style></keyword><keyword><style  face="normal" font="default" size="100%">Frontal Lobe/*growth</style></keyword><keyword><style  face="normal" font="default" size="100%">Genetic</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2013</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Aug 9</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785061/</style></url></web-urls></urls><number><style face="normal" font="default" size="100%">6146</style></number><edition><style face="normal" font="default" size="100%">2013/07/06</style></edition><volume><style face="normal" font="default" size="100%">341</style></volume><pages><style face="normal" font="default" size="100%">1237905</style></pages><isbn><style face="normal" font="default" size="100%">1095-9203 (Electronic)00</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;DNA methylation is implicated in mammalian brain development and plasticity underlying learning and memory. We report the genome-wide composition, patterning, cell specificity, and dynamics of DNA methylation at single-base resolution in human and mouse frontal cortex throughout their lifespan. Widespread methylome reconfiguration occurs during fetal to young adult development, coincident with synaptogenesis. During this period, highly conserved non-CG methylation (mCH) accumulates in neurons, but not glia, to become the dominant form of methylation in the human neuronal genome. Moreover, we found an mCH signature that identifies genes escaping X-chromosome inactivation. Last, whole-genome single-base resolution 5-hydroxymethylcytosine (hmC) maps revealed that hmC marks fetal brain cell genomes at putative regulatory regions that are CG-demethylated and activated in the adult brain and that CG demethylation at these hmC-poised loci depends on Tet2 activity.&lt;/p&gt;
</style></abstract><work-type><style face="normal" font="default" size="100%">Research Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov&#039;tResearch Support, U.S. Gov&#039;t, Non-P.H.S.</style></work-type><accession-num><style face="normal" font="default" size="100%">23828890</style></accession-num><notes><style face="normal" font="default" size="100%">&lt;p&gt;Science. 2013 Aug 9;341(6146):1237905. doi: 10.1126/science.1237905. Epub 2013 Jul 4.&lt;/p&gt;
</style></notes><custom2><style face="normal" font="default" size="100%">3785061</style></custom2><auth-address><style face="normal" font="default" size="100%">Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA. ryan.lister@uwa.edu.au</style></auth-address></record></records></xml>