<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ladoukakis, E D</style></author><author><style face="normal" font="default" size="100%">Eyre-Walker, A</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evolutionary genetics: direct evidence of recombination in human mitochondrial DNA.</style></title><secondary-title><style face="normal" font="default" size="100%">Heredity (Edinb)</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Heredity (Edinb)</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">DNA, Mitochondrial</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Recombination, Genetic</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2004</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2004 Oct</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/15329668</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">93</style></volume><pages><style face="normal" font="default" size="100%">321</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;[Commentary paper]&lt;br /&gt;
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	Over the last 5 years, there has been considerable debate as to whether there is recombination in human mitochondrial DNA (mtDNA) (for references, see &lt;a aria-label=&quot;Reference Piganeau and Eyre-Walker, 2004&quot; data-test=&quot;citation-ref&quot; data-track=&quot;click&quot; data-track-action=&quot;reference anchor&quot; data-track-label=&quot;link&quot; href=&quot;https://www.nature.com/articles/6800572#ref-CR6&quot; id=&quot;ref-link-section-d302441332e255&quot; title=&quot;Piganeau G, Eyre-Walker A (2004). Heredity 92: 282–288.&quot;&gt;Piganeau and Eyre-Walker, 2004&lt;/a&gt;). That debate appears to have finally come to an end with the publication of some direct evidence of recombination. &lt;a aria-label=&quot;Reference Schwartz and Vissing (2002)&quot; data-test=&quot;citation-ref&quot; data-track=&quot;click&quot; data-track-action=&quot;reference anchor&quot; data-track-label=&quot;link&quot; href=&quot;https://www.nature.com/articles/6800572#ref-CR8&quot; id=&quot;ref-link-section-d302441332e258&quot; title=&quot;Schwartz M, Vissing J (2002). N Engl J Med 347: 576–580.&quot;&gt;Schwartz and Vissing (2002)&lt;/a&gt;, 2 years ago, presented the case of a 28-year-old man who had both maternal and paternally derived mtDNA in his muscle tissue &amp;ndash; in all his other tissues he had only maternally derived mtDNA. It was the first time that paternal leakage and, consequently, heteroplasmy was observed in human mtDNA. In a recent paper, &lt;a aria-label=&quot;Reference Kraytsberg et al (2004)&quot; data-test=&quot;citation-ref&quot; data-track=&quot;click&quot; data-track-action=&quot;reference anchor&quot; data-track-label=&quot;link&quot; href=&quot;https://www.nature.com/articles/6800572#ref-CR5&quot; id=&quot;ref-link-section-d302441332e261&quot; title=&quot;Kraytsberg Y, Schwartz M, Brown TA, Ebralidse K, Kunz WS, Clayton DA et al (2004). Science 304: 981.&quot;&gt;Kraytsberg et al (2004)&lt;/a&gt; take this observation one step further, and claim to show that there has been recombination between the maternal and paternal mtDNA in this individual.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><notes><style face="normal" font="default" size="100%">&lt;p&gt;http://www.nature.com/hdy/journal/v93/n4/full/6800572a.html&lt;/p&gt;
</style></notes><custom1><style face="normal" font="default" size="100%">&lt;p&gt;http://www.ncbi.nlm.nih.gov/pubmed/15329668?dopt=Abstract&lt;/p&gt;
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