<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sankararaman, Sriram</style></author><author><style face="normal" font="default" size="100%">Mallick, Swapan</style></author><author><style face="normal" font="default" size="100%">Patterson, Nick</style></author><author><style face="normal" font="default" size="100%">Reich, David</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Combined Landscape of Denisovan and Neanderthal Ancestry in Present-Day Humans.</style></title><secondary-title><style face="normal" font="default" size="100%">Curr Biol</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Curr. Biol.</style></alt-title></titles><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2016 May 9</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/27032491</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">26</style></volume><pages><style face="normal" font="default" size="100%">1241-7</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Some present-day humans derive up to ∼5% [1] of&amp;nbsp;their ancestry from archaic Denisovans, an even&amp;nbsp;larger proportion than the ∼2% from Neanderthals [2]. We developed methods that can disambiguate the locations of segments of Denisovan and Neanderthal ancestry in present-day humans and applied them to 257 high-coverage genomes from 120 diverse populations, among which were 20 individual Oceanians with high Denisovan ancestry [3]. In Oceanians, the average size of Denisovan fragments is larger than Neanderthal fragments, implying a more recent average date of Denisovan admixture in the history of these populations (p&amp;nbsp;= 0.00004). We document more Denisovan ancestry in South Asia than is expected based on existing models of&amp;nbsp;history, reflecting a previously undocumented mixture related to archaic humans (p&amp;nbsp;= 0.0013). Denisovan ancestry, just like Neanderthal ancestry, has been deleterious on a modern human genetic background, as reflected by its depletion near genes. Finally, the reduction of both archaic ancestries is especially pronounced on chromosome X and near genes more highly expressed in testes than other tissues (p&amp;nbsp;= 1.2&amp;nbsp;× 10(-7) to 3.2&amp;nbsp;× 10(-7) for Denisovan and 2.2&amp;nbsp;× 10(-3) to 2.9&amp;nbsp;× 10(-3) for Neanderthal ancestry even after controlling for differences in level of selective constraint across gene classes). This suggests that reduced male fertility may be a general feature of mixtures of human populations diverged by &amp;gt;500,000 years.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">9</style></issue><notes><style face="normal" font="default" size="100%">&lt;p&gt;http://www.cell.com/current-biology/fulltext/S0960-9822%2816%2930247-0&lt;/p&gt;
</style></notes><custom1><style face="normal" font="default" size="100%">&lt;p&gt;http://www.ncbi.nlm.nih.gov/pubmed/27032491?dopt=Abstract&lt;/p&gt;
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