<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Reilly, Steven K</style></author><author><style face="normal" font="default" size="100%">Yin, Jun</style></author><author><style face="normal" font="default" size="100%">Ayoub, Albert E</style></author><author><style face="normal" font="default" size="100%">Emera, Deena</style></author><author><style face="normal" font="default" size="100%">Leng, Jing</style></author><author><style face="normal" font="default" size="100%">Cotney, Justin</style></author><author><style face="normal" font="default" size="100%">Sarro, Richard</style></author><author><style face="normal" font="default" size="100%">Rakic, Pasko</style></author><author><style face="normal" font="default" size="100%">Noonan, James P</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evolutionary genomics. Evolutionary changes in promoter and enhancer activity during human corticogenesis.</style></title><secondary-title><style face="normal" font="default" size="100%">Science</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Science</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Animals</style></keyword><keyword><style  face="normal" font="default" size="100%">Cerebral Cortex</style></keyword><keyword><style  face="normal" font="default" size="100%">Enhancer Elements, Genetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Epigenesis, Genetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Evolution, Molecular</style></keyword><keyword><style  face="normal" font="default" size="100%">Gene Expression Regulation, Developmental</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Macaca mulatta</style></keyword><keyword><style  face="normal" font="default" size="100%">Mice</style></keyword><keyword><style  face="normal" font="default" size="100%">Organogenesis</style></keyword><keyword><style  face="normal" font="default" size="100%">Promoter Regions, Genetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Rats</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2015 Mar 6</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/25745175</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">347</style></volume><pages><style face="normal" font="default" size="100%">1155-9</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Human higher cognition is attributed to the evolutionary expansion and elaboration of the human cerebral cortex. However, the genetic mechanisms contributing to these developmental changes are poorly understood. We used comparative epigenetic profiling of human, rhesus macaque, and mouse corticogenesis to identify promoters and enhancers that have gained activity in humans. These gains are significantly enriched in modules of coexpressed genes in the cortex that function in neuronal proliferation, migration, and cortical-map organization. Gain-enriched modules also showed correlated gene expression patterns and similar transcription factor binding site enrichments in promoters and enhancers, suggesting that they are connected by common regulatory mechanisms. Our results reveal coordinated patterns of potential regulatory changes associated with conserved developmental processes during corticogenesis, providing insight into human cortical evolution.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6226</style></issue><notes><style face="normal" font="default" size="100%">&lt;p&gt;http://www.sciencemag.org/content/347/6226/1155.full&lt;/p&gt;
</style></notes><custom1><style face="normal" font="default" size="100%">&lt;p&gt;http://www.ncbi.nlm.nih.gov/pubmed/25745175?dopt=Abstract&lt;/p&gt;
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