<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Florio, Marta</style></author><author><style face="normal" font="default" size="100%">Albert, Mareike</style></author><author><style face="normal" font="default" size="100%">Taverna, Elena</style></author><author><style face="normal" font="default" size="100%">Namba, Takashi</style></author><author><style face="normal" font="default" size="100%">Brandl, Holger</style></author><author><style face="normal" font="default" size="100%">Lewitus, Eric</style></author><author><style face="normal" font="default" size="100%">Haffner, Christiane</style></author><author><style face="normal" font="default" size="100%">Sykes, Alex</style></author><author><style face="normal" font="default" size="100%">Wong, Fong Kuan</style></author><author><style face="normal" font="default" size="100%">Peters, Jula</style></author><author><style face="normal" font="default" size="100%">Guhr, Elaine</style></author><author><style face="normal" font="default" size="100%">Klemroth, Sylvia</style></author><author><style face="normal" font="default" size="100%">Prüfer, Kay</style></author><author><style face="normal" font="default" size="100%">Kelso, Janet</style></author><author><style face="normal" font="default" size="100%">Naumann, Ronald</style></author><author><style face="normal" font="default" size="100%">Nüsslein, Ina</style></author><author><style face="normal" font="default" size="100%">Dahl, Andreas</style></author><author><style face="normal" font="default" size="100%">Lachmann, Robert</style></author><author><style face="normal" font="default" size="100%">Pääbo, Svante</style></author><author><style face="normal" font="default" size="100%">Huttner, Wieland B</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Human-specific gene ARHGAP11B promotes basal progenitor amplification and neocortex expansion.</style></title><secondary-title><style face="normal" font="default" size="100%">Science</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Science</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Animals</style></keyword><keyword><style  face="normal" font="default" size="100%">Cell Separation</style></keyword><keyword><style  face="normal" font="default" size="100%">Gene Duplication</style></keyword><keyword><style  face="normal" font="default" size="100%">Gene Expression Regulation, Developmental</style></keyword><keyword><style  face="normal" font="default" size="100%">GTPase-Activating Proteins</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Lateral Ventricles</style></keyword><keyword><style  face="normal" font="default" size="100%">Mice</style></keyword><keyword><style  face="normal" font="default" size="100%">Neocortex</style></keyword><keyword><style  face="normal" font="default" size="100%">Neural Stem Cells</style></keyword><keyword><style  face="normal" font="default" size="100%">Neurogenesis</style></keyword><keyword><style  face="normal" font="default" size="100%">Neuroglia</style></keyword><keyword><style  face="normal" font="default" size="100%">Neurons</style></keyword><keyword><style  face="normal" font="default" size="100%">Protein Structure, Tertiary</style></keyword><keyword><style  face="normal" font="default" size="100%">Transcriptome</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2015 Mar 27</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/25721503</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">347</style></volume><pages><style face="normal" font="default" size="100%">1465-70</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Evolutionary expansion of the human neocortex reflects increased amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis. In this work, we analyze the transcriptomes of distinct progenitor subpopulations isolated by a cell polarity-based approach from developing mouse and human neocortex. We identify 56 genes preferentially expressed in human apical and basal radial glia that lack mouse orthologs. Among these, ARHGAP11B has the highest degree of radial glia-specific expression. ARHGAP11B arose from partial duplication of ARHGAP11A (which encodes a Rho guanosine triphosphatase-activating protein) on the human lineage after separation from the chimpanzee lineage. Expression of ARHGAP11B in embryonic mouse neocortex promotes basal progenitor generation and self-renewal and can increase cortical plate area and induce gyrification. Hence, ARHGAP11B may have contributed to evolutionary expansion of human neocortex.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6229</style></issue><notes><style face="normal" font="default" size="100%">&lt;p&gt;http://www.sciencemag.org/content/early/2015/02/25/science.aaa1975&lt;/p&gt;
</style></notes><custom1><style face="normal" font="default" size="100%">&lt;p&gt;http://www.ncbi.nlm.nih.gov/pubmed/25721503?dopt=Abstract&lt;/p&gt;
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