<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Cuskin, Fiona</style></author><author><style face="normal" font="default" size="100%">Lowe, Elisabeth C</style></author><author><style face="normal" font="default" size="100%">Temple, Max J</style></author><author><style face="normal" font="default" size="100%">Zhu, Yanping</style></author><author><style face="normal" font="default" size="100%">Cameron, Elizabeth A</style></author><author><style face="normal" font="default" size="100%">Pudlo, Nicholas A</style></author><author><style face="normal" font="default" size="100%">Porter, Nathan T</style></author><author><style face="normal" font="default" size="100%">Urs, Karthik</style></author><author><style face="normal" font="default" size="100%">Thompson, Andrew J</style></author><author><style face="normal" font="default" size="100%">Cartmell, Alan</style></author><author><style face="normal" font="default" size="100%">Rogowski, Artur</style></author><author><style face="normal" font="default" size="100%">Hamilton, Brian S</style></author><author><style face="normal" font="default" size="100%">Chen, Rui</style></author><author><style face="normal" font="default" size="100%">Tolbert, Thomas J</style></author><author><style face="normal" font="default" size="100%">Piens, Kathleen</style></author><author><style face="normal" font="default" size="100%">Bracke, Debby</style></author><author><style face="normal" font="default" size="100%">Vervecken, Wouter</style></author><author><style face="normal" font="default" size="100%">Hakki, Zalihe</style></author><author><style face="normal" font="default" size="100%">Speciale, Gaetano</style></author><author><style face="normal" font="default" size="100%">Munōz-Munōz, Jose L</style></author><author><style face="normal" font="default" size="100%">Day, Andrew</style></author><author><style face="normal" font="default" size="100%">Peña, Maria J</style></author><author><style face="normal" font="default" size="100%">McLean, Richard</style></author><author><style face="normal" font="default" size="100%">Suits, Michael D</style></author><author><style face="normal" font="default" size="100%">Boraston, Alisdair B</style></author><author><style face="normal" font="default" size="100%">Atherly, Todd</style></author><author><style face="normal" font="default" size="100%">Ziemer, Cherie J</style></author><author><style face="normal" font="default" size="100%">Williams, Spencer J</style></author><author><style face="normal" font="default" size="100%">Davies, Gideon J</style></author><author><style face="normal" font="default" size="100%">Abbott, D Wade</style></author><author><style face="normal" font="default" size="100%">Martens, Eric C</style></author><author><style face="normal" font="default" size="100%">Gilbert, Harry J</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Human gut Bacteroidetes can utilize yeast mannan through a selfish mechanism.</style></title><secondary-title><style face="normal" font="default" size="100%">Nature</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Nature</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Animals</style></keyword><keyword><style  face="normal" font="default" size="100%">Bacteroidetes</style></keyword><keyword><style  face="normal" font="default" size="100%">Biological Evolution</style></keyword><keyword><style  face="normal" font="default" size="100%">Carbohydrate Conformation</style></keyword><keyword><style  face="normal" font="default" size="100%">Diet</style></keyword><keyword><style  face="normal" font="default" size="100%">Enzymes</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Gastrointestinal Tract</style></keyword><keyword><style  face="normal" font="default" size="100%">Genetic Loci</style></keyword><keyword><style  face="normal" font="default" size="100%">Germ-Free Life</style></keyword><keyword><style  face="normal" font="default" size="100%">Glycoproteins</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">Mannans</style></keyword><keyword><style  face="normal" font="default" size="100%">Mannose</style></keyword><keyword><style  face="normal" font="default" size="100%">Mice</style></keyword><keyword><style  face="normal" font="default" size="100%">Models, Biological</style></keyword><keyword><style  face="normal" font="default" size="100%">Models, Molecular</style></keyword><keyword><style  face="normal" font="default" size="100%">Oligosaccharides</style></keyword><keyword><style  face="normal" font="default" size="100%">Periplasm</style></keyword><keyword><style  face="normal" font="default" size="100%">Yeasts</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2015 Jan 8</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/25567280</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">517</style></volume><pages><style face="normal" font="default" size="100%">165-9</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Yeasts, which have been a component of the human diet for at least 7,000 years, possess an elaborate cell wall α-mannan. The influence of yeast mannan on the ecology of the human microbiota is unknown. Here we show that yeast α-mannan is a viable food source for the Gram-negative bacterium Bacteroides thetaiotaomicron, a dominant member of the microbiota. Detailed biochemical analysis and targeted gene disruption studies support a model whereby limited cleavage of α-mannan on the surface generates large oligosaccharides that are subsequently depolymerized to mannose by the action of periplasmic enzymes. Co-culturing studies showed that metabolism of yeast mannan by B. thetaiotaomicron presents a &#039;selfish&#039; model for the catabolism of this difficult to breakdown polysaccharide. Genomic comparison with B. thetaiotaomicron in conjunction with cell culture studies show that a cohort of highly successful members of the microbiota has evolved to consume sterically-restricted yeast glycans, an adaptation that may reflect the incorporation of eukaryotic microorganisms into the human diet.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">7533</style></issue><notes><style face="normal" font="default" size="100%">http://www.nature.com/nature/journal/v517/n7533/full/nature13995.html</style></notes><custom1><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/25567280?dopt=Abstract</style></custom1></record></records></xml>