<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dutilh, Bas E</style></author><author><style face="normal" font="default" size="100%">Cassman, Noriko</style></author><author><style face="normal" font="default" size="100%">McNair, Katelyn</style></author><author><style face="normal" font="default" size="100%">Sanchez, Savannah E</style></author><author><style face="normal" font="default" size="100%">Silva, Genivaldo G Z</style></author><author><style face="normal" font="default" size="100%">Boling, Lance</style></author><author><style face="normal" font="default" size="100%">Barr, Jeremy J</style></author><author><style face="normal" font="default" size="100%">Speth, Daan R</style></author><author><style face="normal" font="default" size="100%">Seguritan, Victor</style></author><author><style face="normal" font="default" size="100%">Aziz, Ramy K</style></author><author><style face="normal" font="default" size="100%">Felts, Ben</style></author><author><style face="normal" font="default" size="100%">Dinsdale, Elizabeth A</style></author><author><style face="normal" font="default" size="100%">Mokili, John L</style></author><author><style face="normal" font="default" size="100%">Edwards, Robert A</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">A highly abundant bacteriophage discovered in the unknown sequences of human faecal metagenomes.</style></title><secondary-title><style face="normal" font="default" size="100%">Nat Commun</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Nat Commun</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Bacteriophages</style></keyword><keyword><style  face="normal" font="default" size="100%">Bacteroides</style></keyword><keyword><style  face="normal" font="default" size="100%">Clustered Regularly Interspaced Short Palindromic Repeats</style></keyword><keyword><style  face="normal" font="default" size="100%">Feces</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Metagenome</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular Sequence Data</style></keyword><keyword><style  face="normal" font="default" size="100%">Viral Proteins</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2014</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/25058116</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">5</style></volume><pages><style face="normal" font="default" size="100%">4498</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Metagenomics, or sequencing of the genetic material from a complete microbial community, is a promising tool to discover novel microbes and viruses. Viral metagenomes typically contain many unknown sequences. Here we describe the discovery of a previously unidentified bacteriophage present in the majority of published human faecal metagenomes, which we refer to as crAssphage. Its ~97 kbp genome is six times more abundant in publicly available metagenomes than all other known phages together; it comprises up to 90% and 22% of all reads in virus-like particle (VLP)-derived metagenomes and total community metagenomes, respectively; and it totals 1.68% of all human faecal metagenomic sequencing reads in the public databases. The majority of crAssphage-encoded proteins match no known sequences in the database, which is why it was not detected before. Using a new co-occurrence profiling approach, we predict a Bacteroides host for this phage, consistent with Bacteroides-related protein homologues and a unique carbohydrate-binding domain encoded in the phage genome.&lt;/p&gt;</style></abstract><notes><style face="normal" font="default" size="100%">http://www.nature.com/ncomms/2014/140724/ncomms5498/full/ncomms5498.html</style></notes><custom1><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/25058116?dopt=Abstract</style></custom1></record></records></xml>