<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Bundo, Miki</style></author><author><style face="normal" font="default" size="100%">Toyoshima, Manabu</style></author><author><style face="normal" font="default" size="100%">Okada, Yohei</style></author><author><style face="normal" font="default" size="100%">Akamatsu, Wado</style></author><author><style face="normal" font="default" size="100%">Ueda, Junko</style></author><author><style face="normal" font="default" size="100%">Nemoto-Miyauchi, Taeko</style></author><author><style face="normal" font="default" size="100%">Sunaga, Fumiko</style></author><author><style face="normal" font="default" size="100%">Toritsuka, Michihiro</style></author><author><style face="normal" font="default" size="100%">Ikawa, Daisuke</style></author><author><style face="normal" font="default" size="100%">Kakita, Akiyoshi</style></author><author><style face="normal" font="default" size="100%">Kato, Motoichiro</style></author><author><style face="normal" font="default" size="100%">Kasai, Kiyoto</style></author><author><style face="normal" font="default" size="100%">Kishimoto, Toshifumi</style></author><author><style face="normal" font="default" size="100%">Nawa, Hiroyuki</style></author><author><style face="normal" font="default" size="100%">Okano, Hideyuki</style></author><author><style face="normal" font="default" size="100%">Yoshikawa, Takeo</style></author><author><style face="normal" font="default" size="100%">Kato, Tadafumi</style></author><author><style face="normal" font="default" size="100%">Iwamoto, Kazuya</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Increased l1 retrotransposition in the neuronal genome in schizophrenia.</style></title><secondary-title><style face="normal" font="default" size="100%">Neuron</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Neuron</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">22q11 Deletion Syndrome</style></keyword><keyword><style  face="normal" font="default" size="100%">Adult</style></keyword><keyword><style  face="normal" font="default" size="100%">Animals</style></keyword><keyword><style  face="normal" font="default" size="100%">Animals, Newborn</style></keyword><keyword><style  face="normal" font="default" size="100%">Cells, Cultured</style></keyword><keyword><style  face="normal" font="default" size="100%">Disease Models, Animal</style></keyword><keyword><style  face="normal" font="default" size="100%">DNA Copy Number Variations</style></keyword><keyword><style  face="normal" font="default" size="100%">DNA Transposable Elements</style></keyword><keyword><style  face="normal" font="default" size="100%">Endogenous Retroviruses</style></keyword><keyword><style  face="normal" font="default" size="100%">Endonucleases</style></keyword><keyword><style  face="normal" font="default" size="100%">Epidermal Growth Factor</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Fibroblasts</style></keyword><keyword><style  face="normal" font="default" size="100%">Gene Ontology</style></keyword><keyword><style  face="normal" font="default" size="100%">Genetic Predisposition to Disease</style></keyword><keyword><style  face="normal" font="default" size="100%">Genome</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Macaca fascicularis</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">Mice</style></keyword><keyword><style  face="normal" font="default" size="100%">Mice, Inbred C57BL</style></keyword><keyword><style  face="normal" font="default" size="100%">Middle Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Neurons</style></keyword><keyword><style  face="normal" font="default" size="100%">Phosphopyruvate Hydratase</style></keyword><keyword><style  face="normal" font="default" size="100%">Pluripotent Stem Cells</style></keyword><keyword><style  face="normal" font="default" size="100%">Poly I-C</style></keyword><keyword><style  face="normal" font="default" size="100%">Postmortem Changes</style></keyword><keyword><style  face="normal" font="default" size="100%">Prefrontal Cortex</style></keyword><keyword><style  face="normal" font="default" size="100%">Pregnancy</style></keyword><keyword><style  face="normal" font="default" size="100%">Pregnancy Proteins</style></keyword><keyword><style  face="normal" font="default" size="100%">Rett Syndrome</style></keyword><keyword><style  face="normal" font="default" size="100%">Risk Factors</style></keyword><keyword><style  face="normal" font="default" size="100%">RNA-Directed DNA Polymerase</style></keyword><keyword><style  face="normal" font="default" size="100%">Schizophrenia</style></keyword><keyword><style  face="normal" font="default" size="100%">Transfection</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2014 Jan 22</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/24389010</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">81</style></volume><pages><style face="normal" font="default" size="100%">306-13</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Recent studies indicate that long interspersed nuclear element-1 (L1) are mobilized in the genome of human neural progenitor cells and enhanced in Rett syndrome and ataxia telangiectasia. However, whether aberrant L1 retrotransposition occurs in mental disorders is unknown. Here, we report high L1 copy number in schizophrenia. Increased L1 was demonstrated in neurons from prefrontal cortex of patients and in induced pluripotent stem (iPS) cell-derived neurons containing 22q11 deletions. Whole-genome sequencing revealed brain-specific L1 insertion in patients localized preferentially to synapse- and schizophrenia-related genes. To study the mechanism of L1 transposition, we examined perinatal environmental risk factors for schizophrenia in animal models and observed an increased L1 copy number after immune activation by poly-I:C or epidermal growth factor. These findings suggest that hyperactive retrotransposition of L1 in neurons triggered by environmental and/or genetic risk factors may contribute to the susceptibility and pathophysiology of schizophrenia.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><notes><style face="normal" font="default" size="100%">http://www.sciencedirect.com/science/article/pii/S0896627313010052</style></notes><custom1><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/24389010?dopt=Abstract</style></custom1></record></records></xml>