<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Stergachis, Andrew B</style></author><author><style face="normal" font="default" size="100%">Haugen, Eric</style></author><author><style face="normal" font="default" size="100%">Shafer, Anthony</style></author><author><style face="normal" font="default" size="100%">Fu, Wenqing</style></author><author><style face="normal" font="default" size="100%">Vernot, Benjamin</style></author><author><style face="normal" font="default" size="100%">Reynolds, Alex</style></author><author><style face="normal" font="default" size="100%">Raubitschek, Anthony</style></author><author><style face="normal" font="default" size="100%">Ziegler, Steven</style></author><author><style face="normal" font="default" size="100%">LeProust, Emily M</style></author><author><style face="normal" font="default" size="100%">Akey, Joshua M</style></author><author><style face="normal" font="default" size="100%">Stamatoyannopoulos, John A</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Exonic transcription factor binding directs codon choice and affects protein evolution.</style></title><secondary-title><style face="normal" font="default" size="100%">Science</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Science</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Codon</style></keyword><keyword><style  face="normal" font="default" size="100%">Deoxyribonuclease I</style></keyword><keyword><style  face="normal" font="default" size="100%">DNA Footprinting</style></keyword><keyword><style  face="normal" font="default" size="100%">Evolution, Molecular</style></keyword><keyword><style  face="normal" font="default" size="100%">Exome</style></keyword><keyword><style  face="normal" font="default" size="100%">Exons</style></keyword><keyword><style  face="normal" font="default" size="100%">Genome, Human</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Polymorphism, Single Nucleotide</style></keyword><keyword><style  face="normal" font="default" size="100%">Transcription Factors</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2013</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2013 Dec 13</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/24337295</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">342</style></volume><pages><style face="normal" font="default" size="100%">1367-72</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Genomes contain both a genetic code specifying amino acids and a regulatory code specifying transcription factor (TF) recognition sequences. We used genomic deoxyribonuclease I footprinting to map nucleotide resolution TF occupancy across the human exome in 81 diverse cell types. We found that ~15% of human codons are dual-use codons (&quot;duons&quot;) that simultaneously specify both amino acids and TF recognition sites. Duons are highly conserved and have shaped protein evolution, and TF-imposed constraint appears to be a major driver of codon usage bias. Conversely, the regulatory code has been selectively depleted of TFs that recognize stop codons. More than 17% of single-nucleotide variants within duons directly alter TF binding. Pervasive dual encoding of amino acid and regulatory information appears to be a fundamental feature of genome evolution.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6164</style></issue><notes><style face="normal" font="default" size="100%">http://www.sciencemag.org/content/342/6164/1367.full</style></notes><custom1><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/24337295?dopt=Abstract</style></custom1></record></records></xml>