<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dias, Brian G</style></author><author><style face="normal" font="default" size="100%">Ressler, Kerry J</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Parental olfactory experience influences behavior and neural structure in subsequent generations.</style></title><secondary-title><style face="normal" font="default" size="100%">Nat Neurosci</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Nat. Neurosci.</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">1-Propanol</style></keyword><keyword><style  face="normal" font="default" size="100%">Acetophenones</style></keyword><keyword><style  face="normal" font="default" size="100%">Acoustic Stimulation</style></keyword><keyword><style  face="normal" font="default" size="100%">Analysis of Variance</style></keyword><keyword><style  face="normal" font="default" size="100%">Animals</style></keyword><keyword><style  face="normal" font="default" size="100%">beta-Galactosidase</style></keyword><keyword><style  face="normal" font="default" size="100%">Chromatin Immunoprecipitation</style></keyword><keyword><style  face="normal" font="default" size="100%">Conditioning, Classical</style></keyword><keyword><style  face="normal" font="default" size="100%">Electroshock</style></keyword><keyword><style  face="normal" font="default" size="100%">Epigenomics</style></keyword><keyword><style  face="normal" font="default" size="100%">Fear</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Glycine</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">Mice</style></keyword><keyword><style  face="normal" font="default" size="100%">Mice, Transgenic</style></keyword><keyword><style  face="normal" font="default" size="100%">Odors</style></keyword><keyword><style  face="normal" font="default" size="100%">Olfactory Pathways</style></keyword><keyword><style  face="normal" font="default" size="100%">Paternal Exposure</style></keyword><keyword><style  face="normal" font="default" size="100%">Pregnancy</style></keyword><keyword><style  face="normal" font="default" size="100%">Receptors, Odorant</style></keyword><keyword><style  face="normal" font="default" size="100%">Reflex, Startle</style></keyword><keyword><style  face="normal" font="default" size="100%">Sensory Receptor Cells</style></keyword><keyword><style  face="normal" font="default" size="100%">Smell</style></keyword><keyword><style  face="normal" font="default" size="100%">Spermatozoa</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2014 Jan</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/24292232</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">89-96</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Using olfactory molecular specificity, we examined the inheritance of parental traumatic exposure, a phenomenon that has been frequently observed, but not understood. We subjected F0 mice to odor fear conditioning before conception and found that subsequently conceived F1 and F2 generations had an increased behavioral sensitivity to the F0-conditioned odor, but not to other odors. When an odor (acetophenone) that activates a known odorant receptor (Olfr151) was used to condition F0 mice, the behavioral sensitivity of the F1 and F2 generations to acetophenone was complemented by an enhanced neuroanatomical representation of the Olfr151 pathway. Bisulfite sequencing of sperm DNA from conditioned F0 males and F1 naive offspring revealed CpG hypomethylation in the Olfr151 gene. In addition, in vitro fertilization, F2 inheritance and cross-fostering revealed that these transgenerational effects are inherited via parental gametes. Our findings provide a framework for addressing how environmental information may be inherited transgenerationally at behavioral, neuroanatomical and epigenetic levels.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><notes><style face="normal" font="default" size="100%">http://www.nature.com/neuro/journal/vaop/ncurrent/full/nn.3594.html</style></notes><custom1><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/24292232?dopt=Abstract</style></custom1></record></records></xml>