<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Temme, Sebastian</style></author><author><style face="normal" font="default" size="100%">Zacharias, Martin</style></author><author><style face="normal" font="default" size="100%">Neumann, Jürgen</style></author><author><style face="normal" font="default" size="100%">Wohlfromm, Sebastian</style></author><author><style face="normal" font="default" size="100%">König, Angelika</style></author><author><style face="normal" font="default" size="100%">Temme, Nadine</style></author><author><style face="normal" font="default" size="100%">Springer, Sebastian</style></author><author><style face="normal" font="default" size="100%">Trowsdale, John</style></author><author><style face="normal" font="default" size="100%">Koch, Norbert</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">A novel family of human leukocyte antigen class II receptors may have its origin in archaic human species.</style></title><secondary-title><style face="normal" font="default" size="100%">J Biol Chem</style></secondary-title><alt-title><style face="normal" font="default" size="100%">J. Biol. Chem.</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Amino Acid Sequence</style></keyword><keyword><style  face="normal" font="default" size="100%">Animals</style></keyword><keyword><style  face="normal" font="default" size="100%">Antigens, Differentiation, B-Lymphocyte</style></keyword><keyword><style  face="normal" font="default" size="100%">Binding Sites</style></keyword><keyword><style  face="normal" font="default" size="100%">Cell Line</style></keyword><keyword><style  face="normal" font="default" size="100%">Cercopithecus aethiops</style></keyword><keyword><style  face="normal" font="default" size="100%">COS Cells</style></keyword><keyword><style  face="normal" font="default" size="100%">Evolution, Molecular</style></keyword><keyword><style  face="normal" font="default" size="100%">Histocompatibility Antigens Class II</style></keyword><keyword><style  face="normal" font="default" size="100%">HLA-DP alpha-Chains</style></keyword><keyword><style  face="normal" font="default" size="100%">HLA-DP Antigens</style></keyword><keyword><style  face="normal" font="default" size="100%">HLA-DP beta-Chains</style></keyword><keyword><style  face="normal" font="default" size="100%">HLA-DR alpha-Chains</style></keyword><keyword><style  face="normal" font="default" size="100%">HLA-DR Antigens</style></keyword><keyword><style  face="normal" font="default" size="100%">HLA-DR beta-Chains</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Immunoblotting</style></keyword><keyword><style  face="normal" font="default" size="100%">Models, Molecular</style></keyword><keyword><style  face="normal" font="default" size="100%">Mutation</style></keyword><keyword><style  face="normal" font="default" size="100%">Neanderthals</style></keyword><keyword><style  face="normal" font="default" size="100%">Protein Binding</style></keyword><keyword><style  face="normal" font="default" size="100%">Protein Multimerization</style></keyword><keyword><style  face="normal" font="default" size="100%">Protein Structure, Tertiary</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2014 Jan 10</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/24214983</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">289</style></volume><pages><style face="normal" font="default" size="100%">639-53</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;HLA class II α and β chains form receptors for antigen presentation to CD4(+) T cells. Numerous pairings of class II α and β subunits from the wide range of haplotypes and isotypes may form, but most of these combinations, in particular those produced by isotype mixing, yielded mismatched dimers. It is unclear how selection of functional receptors is achieved. At the atomic level, it is not known which interactions of class II residues regulate selection of matched αβ heterodimers and the evolutionary origin of matched isotype mixed dimer formation. In this study we investigated assembly of isotype-mixed HLA class II α and β heterodimers. Assembly and carbohydrate maturation of various HLA-class II isotype-mixed α and β subunits was dependent on the groove binding section of the invariant chain (Ii). By mutation of polymorphic DPβ sequences, we identified two motifs, Lys-69 and GGPM-(84-87), that are engaged in Ii-dependent assembly of DPβ with DRα. We identified five members of a family of DPβ chains containing Lys-69 and GGPM 84-87, which assemble with DRα. The Lys/GGPM motif is present in the DPβ sequence of the Neanderthal genome, and this ancient sequence is related to the human allele DPB1*0401. By site-directed mutagenesis, we inspected Neanderthal amino acid residues that differ from the DPB1*0401 allele and aimed to determine whether matched heterodimers are formed by assembly of DPβ mutants with DRα. Because the *0401 allele is rare in the sub-Saharan population but frequent in the European population, it may have arisen in modern humans by admixture with Neanderthals in Europe.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><notes><style face="normal" font="default" size="100%">&lt;p&gt;http://www.jbc.org/content/early/2013/11/08/jbc.M113.515767&lt;/p&gt;
</style></notes><custom1><style face="normal" font="default" size="100%">&lt;p&gt;http://www.ncbi.nlm.nih.gov/pubmed/24214983?dopt=Abstract&lt;/p&gt;
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