<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Glahn, David C</style></author><author><style face="normal" font="default" size="100%">Kent, Jack W</style></author><author><style face="normal" font="default" size="100%">Sprooten, Emma</style></author><author><style face="normal" font="default" size="100%">Diego, Vincent P</style></author><author><style face="normal" font="default" size="100%">Winkler, Anderson M</style></author><author><style face="normal" font="default" size="100%">Curran, Joanne E</style></author><author><style face="normal" font="default" size="100%">McKay, D Reese</style></author><author><style face="normal" font="default" size="100%">Knowles, Emma E</style></author><author><style face="normal" font="default" size="100%">Carless, Melanie A</style></author><author><style face="normal" font="default" size="100%">Göring, Harald H H</style></author><author><style face="normal" font="default" size="100%">Dyer, Thomas D</style></author><author><style face="normal" font="default" size="100%">Olvera, Rene L</style></author><author><style face="normal" font="default" size="100%">Fox, Peter T</style></author><author><style face="normal" font="default" size="100%">Almasy, Laura</style></author><author><style face="normal" font="default" size="100%">Charlesworth, Jac</style></author><author><style face="normal" font="default" size="100%">Kochunov, Peter</style></author><author><style face="normal" font="default" size="100%">Duggirala, Ravi</style></author><author><style face="normal" font="default" size="100%">Blangero, John</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Genetic basis of neurocognitive decline and reduced white-matter integrity in normal human brain aging.</style></title><secondary-title><style face="normal" font="default" size="100%">Proc Natl Acad Sci U S A</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Proc. Natl. Acad. Sci. U.S.A.</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Adult</style></keyword><keyword><style  face="normal" font="default" size="100%">Age Factors</style></keyword><keyword><style  face="normal" font="default" size="100%">Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Aged, 80 and over</style></keyword><keyword><style  face="normal" font="default" size="100%">Aging</style></keyword><keyword><style  face="normal" font="default" size="100%">Analysis of Variance</style></keyword><keyword><style  face="normal" font="default" size="100%">Anisotropy</style></keyword><keyword><style  face="normal" font="default" size="100%">Brain</style></keyword><keyword><style  face="normal" font="default" size="100%">Cognition</style></keyword><keyword><style  face="normal" font="default" size="100%">Diffusion tensor imaging</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Memory disorders</style></keyword><keyword><style  face="normal" font="default" size="100%">Mexican Americans</style></keyword><keyword><style  face="normal" font="default" size="100%">Middle Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Nerve Fibers, Myelinated</style></keyword><keyword><style  face="normal" font="default" size="100%">Neuroimaging</style></keyword><keyword><style  face="normal" font="default" size="100%">Pedigree</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2013</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2013 Nov 19</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/24191011</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">110</style></volume><pages><style face="normal" font="default" size="100%">19006-11</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Identification of genes associated with brain aging should markedly improve our understanding of the biological processes that govern normal age-related decline. However, challenges to identifying genes that facilitate successful brain aging are considerable, including a lack of established phenotypes and difficulties in modeling the effects of aging per se, rather than genes that influence the underlying trait. In a large cohort of randomly selected pedigrees (n = 1,129 subjects), we documented profound aging effects from young adulthood to old age (18-83 y) on neurocognitive ability and diffusion-based white-matter measures. Despite significant phenotypic correlation between white-matter integrity and tests of processing speed, working memory, declarative memory, and intelligence, no evidence for pleiotropy between these classes of phenotypes was observed. Applying an advanced quantitative gene-by-environment interaction analysis where age is treated as an environmental factor, we demonstrate a heritable basis for neurocognitive deterioration as a function of age. Furthermore, by decomposing gene-by-aging (G × A) interactions, we infer that different genes influence some neurocognitive traits as a function of age, whereas other neurocognitive traits are influenced by the same genes, but to differential levels, from young adulthood to old age. In contrast, increasing white-matter incoherence with age appears to be nongenetic. These results clearly demonstrate that traits sensitive to the genetic influences on brain aging can be identified, a critical first step in delineating the biological mechanisms of successful aging.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">47</style></issue><notes><style face="normal" font="default" size="100%">http://www.pnas.org/content/early/2013/10/30/1313735110.abstract</style></notes><custom1><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/24191011?dopt=Abstract</style></custom1></record></records></xml>