<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Hansen, John-Bjarne</style></author><author><style face="normal" font="default" size="100%">Fernández, José A</style></author><author><style face="normal" font="default" size="100%">Notø, Ann-Trude With</style></author><author><style face="normal" font="default" size="100%">Deguchi, Hiroshi</style></author><author><style face="normal" font="default" size="100%">Björkegren, Johan</style></author><author><style face="normal" font="default" size="100%">Mathiesen, Ellisiv B</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The apolipoprotein C-I content of very-low-density lipoproteins is associated with fasting triglycerides, postprandial lipemia, and carotid atherosclerosis.</style></title><secondary-title><style face="normal" font="default" size="100%">J Lipids</style></secondary-title><alt-title><style face="normal" font="default" size="100%">J Lipids</style></alt-title></titles><dates><year><style  face="normal" font="default" size="100%">2011</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2011</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">2011</style></volume><pages><style face="normal" font="default" size="100%">271062</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Background. Experimental studies in animals suggest that apolipoprotein (apo) C-I is an important regulator of triglycerides in fasting and postprandial conditions and associated with carotid atherosclerosis. Methods. A cross-sectional study was conducted with 81 subjects, aged 56-80 years recruited from a population health survey. The participants underwent a fat tolerance test (1 g fat per Kg body weight) and carotid atherosclerosis was determined by ultrasound examination. VLDL particles, Sf 20-400, were isolated and their lipid composition and apoC-I content determined. Results. The carotid plaque area increased linearly with the number of apoC-I molecules per VLDL particles (P = 0.048) under fasting conditions. Fasting triglycerides increased across tertiles of apoC-I per VLDL particle in analyses adjusted for apoC-II and -C-III, apoE genotype and traditional cardiovascular risk factors (P = 0.011). The relation between apoC-I in VLDL and serum triglycerides was conveyed by triglyceride enrichment of VLDL particles (P for trend &amp;lt;0.001. The amount of apoC-I molecules per VLDL was correlated with the total (r = 0.41, P &amp;lt; 0.0001) and incremental (r = 0.35, P &amp;lt; 0.001) area under the postprandial triglyceride curve. Conclusions. Our findings support the concept that the content of apoC-I per VLDL particle is an important regulator of triglyceride metabolism in the fasting and postprandial state and associated with carotid athrosclerosis.&lt;/p&gt;
</style></abstract><custom1><style face="normal" font="default" size="100%">&lt;p&gt;http://www.ncbi.nlm.nih.gov/pubmed/21776394?dopt=Abstract&lt;/p&gt;
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