<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mendez, F. L.</style></author><author><style face="normal" font="default" size="100%">Watkins, J. C.</style></author><author><style face="normal" font="default" size="100%">Hammer, M. F.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Neandertal origin of genetic variation at the cluster of OAS immunity genes</style></title><secondary-title><style face="normal" font="default" size="100%">Mol. Bio. Evol. </style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2013</style></year></dates><volume><style face="normal" font="default" size="100%">30</style></volume><pages><style face="normal" font="default" size="100%">798-801</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Analyses of ancient DNA from extinct humans reveal signals of at least two independent hybridization events in the history of non-African populations. To date there are very few examples of specific genetic variants that have been rigorously identified as introgressive. Here we survey DNA sequence variation in the&amp;nbsp;OAS&amp;nbsp;gene cluster on chromosome 12 and provide strong evidence that a haplotype extending for ~185 kb introgressed from Neandertals. This haplotype is nearly restricted to Eurasians and is estimated to have diverged from the Neandertal sequence ~125 kya. Despite the potential for novel functional variation, the observed frequency of this haplotype is consistent with neutral introgression. This is the second locus in the human genome, after&amp;nbsp;STAT2, carrying distinct haplotypes that appear to have introgressed separately from both Neandertals and Denisova.&lt;/p&gt;
</style></abstract></record></records></xml>