<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Currat, Mathias</style></author><author><style face="normal" font="default" size="100%">Excoffier, Laurent</style></author><author><style face="normal" font="default" size="100%">Maddison, Wayne</style></author><author><style face="normal" font="default" size="100%">Otto, Sarah P</style></author><author><style face="normal" font="default" size="100%">Ray, Nicolas</style></author><author><style face="normal" font="default" size="100%">Whitlock, Michael C</style></author><author><style face="normal" font="default" size="100%">Yeaman, Sam</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comment on &quot;Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens&quot; and &quot;Microcephalin, a gene regulating brain size, continues to evolve adaptively in humans&quot;.</style></title><secondary-title><style face="normal" font="default" size="100%">Science</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Science</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Adaptation, Biological</style></keyword><keyword><style  face="normal" font="default" size="100%">Biological Evolution</style></keyword><keyword><style  face="normal" font="default" size="100%">Brain</style></keyword><keyword><style  face="normal" font="default" size="100%">Demography</style></keyword><keyword><style  face="normal" font="default" size="100%">Founder Effect</style></keyword><keyword><style  face="normal" font="default" size="100%">Gene Frequency</style></keyword><keyword><style  face="normal" font="default" size="100%">Haplotypes</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Models, Theoretical</style></keyword><keyword><style  face="normal" font="default" size="100%">Nerve Tissue Proteins</style></keyword><keyword><style  face="normal" font="default" size="100%">Organ Size</style></keyword><keyword><style  face="normal" font="default" size="100%">Population Density</style></keyword><keyword><style  face="normal" font="default" size="100%">Population Growth</style></keyword><keyword><style  face="normal" font="default" size="100%">Selection, Genetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Sequence Analysis, DNA</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2006</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2006 Jul 14</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">313</style></volume><pages><style face="normal" font="default" size="100%">172; author reply 172</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Mekel-Bobrov et al. and Evans et al. (Reports, 9 Sept. 2005, p. 1720 and p. 1717, respectively) examined sequence data from modern humans within two gene regions associated with brain development, ASPM and microcephalin, and concluded that selection of these genes must be ongoing. We show that models of human history that include both population growth and spatial structure can generate the observed patterns without selection.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5784</style></issue><custom1><style face="normal" font="default" size="100%">&lt;p&gt;http://www.ncbi.nlm.nih.gov/pubmed/16840683?dopt=Abstract&lt;/p&gt;
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