<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Lamason, Rebecca L</style></author><author><style face="normal" font="default" size="100%">Mohideen, Manzoor-Ali P K</style></author><author><style face="normal" font="default" size="100%">Mest, Jason R</style></author><author><style face="normal" font="default" size="100%">Wong, Andrew C</style></author><author><style face="normal" font="default" size="100%">Norton, Heather L</style></author><author><style face="normal" font="default" size="100%">Aros, Michele C</style></author><author><style face="normal" font="default" size="100%">Jurynec, Michael J</style></author><author><style face="normal" font="default" size="100%">Mao, Xianyun</style></author><author><style face="normal" font="default" size="100%">Humphreville, Vanessa R</style></author><author><style face="normal" font="default" size="100%">Humbert, Jasper E</style></author><author><style face="normal" font="default" size="100%">Sinha, Soniya</style></author><author><style face="normal" font="default" size="100%">Moore, Jessica L</style></author><author><style face="normal" font="default" size="100%">Jagadeeswaran, Pudur</style></author><author><style face="normal" font="default" size="100%">Zhao, Wei</style></author><author><style face="normal" font="default" size="100%">Ning, Gang</style></author><author><style face="normal" font="default" size="100%">Makalowska, Izabela</style></author><author><style face="normal" font="default" size="100%">McKeigue, Paul M</style></author><author><style face="normal" font="default" size="100%">O&#039;donnell, David</style></author><author><style face="normal" font="default" size="100%">Kittles, Rick</style></author><author><style face="normal" font="default" size="100%">Parra, Esteban J</style></author><author><style face="normal" font="default" size="100%">Mangini, Nancy J</style></author><author><style face="normal" font="default" size="100%">Grunwald, David J</style></author><author><style face="normal" font="default" size="100%">Shriver, Mark D</style></author><author><style face="normal" font="default" size="100%">Canfield, Victor A</style></author><author><style face="normal" font="default" size="100%">Cheng, Keith C</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans.</style></title><secondary-title><style face="normal" font="default" size="100%">Science</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Science</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">African Americans</style></keyword><keyword><style  face="normal" font="default" size="100%">African Continental Ancestry Group</style></keyword><keyword><style  face="normal" font="default" size="100%">Alanine</style></keyword><keyword><style  face="normal" font="default" size="100%">Alleles</style></keyword><keyword><style  face="normal" font="default" size="100%">Amino Acid Sequence</style></keyword><keyword><style  face="normal" font="default" size="100%">Animals</style></keyword><keyword><style  face="normal" font="default" size="100%">Antiporters</style></keyword><keyword><style  face="normal" font="default" size="100%">Asian Continental Ancestry Group</style></keyword><keyword><style  face="normal" font="default" size="100%">Biological Evolution</style></keyword><keyword><style  face="normal" font="default" size="100%">Calcium</style></keyword><keyword><style  face="normal" font="default" size="100%">European Continental Ancestry Group</style></keyword><keyword><style  face="normal" font="default" size="100%">Gene Frequency</style></keyword><keyword><style  face="normal" font="default" size="100%">Genes</style></keyword><keyword><style  face="normal" font="default" size="100%">Genetic Variation</style></keyword><keyword><style  face="normal" font="default" size="100%">Haplotypes</style></keyword><keyword><style  face="normal" font="default" size="100%">Heterozygote</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Ion Transport</style></keyword><keyword><style  face="normal" font="default" size="100%">Melanins</style></keyword><keyword><style  face="normal" font="default" size="100%">Melanosomes</style></keyword><keyword><style  face="normal" font="default" size="100%">Mice</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular Sequence Data</style></keyword><keyword><style  face="normal" font="default" size="100%">Multifactorial Inheritance</style></keyword><keyword><style  face="normal" font="default" size="100%">Mutation</style></keyword><keyword><style  face="normal" font="default" size="100%">Pigment Epithelium of Eye</style></keyword><keyword><style  face="normal" font="default" size="100%">Polymorphism, Single Nucleotide</style></keyword><keyword><style  face="normal" font="default" size="100%">Selection, Genetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Skin Pigmentation</style></keyword><keyword><style  face="normal" font="default" size="100%">Threonine</style></keyword><keyword><style  face="normal" font="default" size="100%">Zebrafish</style></keyword><keyword><style  face="normal" font="default" size="100%">Zebrafish Proteins</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2005</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2005 Dec 16</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">310</style></volume><pages><style face="normal" font="default" size="100%">1782-6</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Lighter variations of pigmentation in humans are associated with diminished number, size, and density of melanosomes, the pigmented organelles of melanocytes. Here we show that zebrafish golden mutants share these melanosomal changes and that golden encodes a putative cation exchanger slc24a5 (nckx5) that localizes to an intracellular membrane, likely the melanosome or its precursor. The human ortholog is highly similar in sequence and functional in zebrafish. The evolutionarily conserved ancestral allele of a human coding polymorphism predominates in African and East Asian populations. In contrast, the variant allele is nearly fixed in European populations, is associated with a substantial reduction in regional heterozygosity, and correlates with lighter skin pigmentation in admixed populations, suggesting a key role for the SLC24A5 gene in human pigmentation.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5755</style></issue><custom1><style face="normal" font="default" size="100%">&lt;p&gt;http://www.ncbi.nlm.nih.gov/pubmed/16357253?dopt=Abstract&lt;/p&gt;
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