<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Grossman, Sharon R</style></author><author><style face="normal" font="default" size="100%">Shlyakhter, Ilya</style></author><author><style face="normal" font="default" size="100%">Shylakhter, Ilya</style></author><author><style face="normal" font="default" size="100%">Karlsson, Elinor K</style></author><author><style face="normal" font="default" size="100%">Byrne, Elizabeth H</style></author><author><style face="normal" font="default" size="100%">Morales, Shannon</style></author><author><style face="normal" font="default" size="100%">Frieden, Gabriel</style></author><author><style face="normal" font="default" size="100%">Hostetter, Elizabeth</style></author><author><style face="normal" font="default" size="100%">Angelino, Elaine</style></author><author><style face="normal" font="default" size="100%">Garber, Manuel</style></author><author><style face="normal" font="default" size="100%">Zuk, Or</style></author><author><style face="normal" font="default" size="100%">Lander, Eric S</style></author><author><style face="normal" font="default" size="100%">Schaffner, Stephen F</style></author><author><style face="normal" font="default" size="100%">Sabeti, Pardis C</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">A composite of multiple signals distinguishes causal variants in regions of positive selection.</style></title><secondary-title><style face="normal" font="default" size="100%">Science</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Science</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Computational Biology</style></keyword><keyword><style  face="normal" font="default" size="100%">DNA, Intergenic</style></keyword><keyword><style  face="normal" font="default" size="100%">Evolution, Molecular</style></keyword><keyword><style  face="normal" font="default" size="100%">Genetic Loci</style></keyword><keyword><style  face="normal" font="default" size="100%">Genetic Variation</style></keyword><keyword><style  face="normal" font="default" size="100%">Genome, Human</style></keyword><keyword><style  face="normal" font="default" size="100%">Haplotypes</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Polymorphism, Genetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Population Groups</style></keyword><keyword><style  face="normal" font="default" size="100%">Regulatory Sequences, Nucleic Acid</style></keyword><keyword><style  face="normal" font="default" size="100%">Selection, Genetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Software</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2010</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2010 Feb 12</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">327</style></volume><pages><style face="normal" font="default" size="100%">883-6</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;The human genome contains hundreds of regions whose patterns of genetic variation indicate recent positive natural selection, yet for most the underlying gene and the advantageous mutation remain unknown. We developed a method, composite of multiple signals (CMS), that combines tests for multiple signals of selection and increases resolution by up to 100-fold. By applying CMS to candidate regions from the International Haplotype Map, we localized population-specific selective signals to 55 kilobases (median), identifying known and novel causal variants. CMS can not just identify individual loci but implicates precise variants selected by evolution.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5967</style></issue><custom1><style face="normal" font="default" size="100%">&lt;p&gt;http://www.ncbi.nlm.nih.gov/pubmed/20056855?dopt=Abstract&lt;/p&gt;
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