<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">De Moerlooze, L</style></author><author><style face="normal" font="default" size="100%">Spencer-Dene, B</style></author><author><style face="normal" font="default" size="100%">Revest, J M</style></author><author><style face="normal" font="default" size="100%">Hajihosseini, M</style></author><author><style face="normal" font="default" size="100%">Rosewell, I</style></author><author><style face="normal" font="default" size="100%">Dickson, C</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis.</style></title><secondary-title><style face="normal" font="default" size="100%">Development</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Development</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Abnormalities, Multiple</style></keyword><keyword><style  face="normal" font="default" size="100%">Animals</style></keyword><keyword><style  face="normal" font="default" size="100%">Bone and Bones</style></keyword><keyword><style  face="normal" font="default" size="100%">Craniofacial Abnormalities</style></keyword><keyword><style  face="normal" font="default" size="100%">Embryonic and Fetal Development</style></keyword><keyword><style  face="normal" font="default" size="100%">Epithelium</style></keyword><keyword><style  face="normal" font="default" size="100%">Exons</style></keyword><keyword><style  face="normal" font="default" size="100%">Heterozygote</style></keyword><keyword><style  face="normal" font="default" size="100%">Integrases</style></keyword><keyword><style  face="normal" font="default" size="100%">Mesoderm</style></keyword><keyword><style  face="normal" font="default" size="100%">Mice</style></keyword><keyword><style  face="normal" font="default" size="100%">Mice, Knockout</style></keyword><keyword><style  face="normal" font="default" size="100%">Protein Isoforms</style></keyword><keyword><style  face="normal" font="default" size="100%">Receptor Protein-Tyrosine Kinases</style></keyword><keyword><style  face="normal" font="default" size="100%">Receptor, Fibroblast Growth Factor, Type 2</style></keyword><keyword><style  face="normal" font="default" size="100%">Receptors, Fibroblast Growth Factor</style></keyword><keyword><style  face="normal" font="default" size="100%">Reverse Transcriptase Polymerase Chain Reaction</style></keyword><keyword><style  face="normal" font="default" size="100%">Signal Transduction</style></keyword><keyword><style  face="normal" font="default" size="100%">Viral Proteins</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2000</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2000 Feb</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">127</style></volume><pages><style face="normal" font="default" size="100%">483-92</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;The fibroblast growth factor receptor 2 gene is differentially spliced to encode two transmembrane tyrosine kinase receptor proteins that have different ligand-binding specificities and exclusive tissue distributions. We have used Cre-mediated excision to generate mice lacking the IIIb form of fibroblast growth factor receptor 2 whilst retaining expression of the IIIc form. Fibroblast growth factor receptor 2(IIIb) null mice are viable until birth, but have severe defects of the limbs, lung and anterior pituitary gland. The development of these structures appears to initiate, but then fails with the tissues undergoing extensive apoptosis. There are also developmental abnormalities of the salivary glands, inner ear, teeth and skin, as well as minor defects in skull formation. Our findings point to a key role for fibroblast growth factor receptor 2(IIIb) in mesenchymal-epithelial signalling during early organogenesis.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><custom1><style face="normal" font="default" size="100%">&lt;p&gt;http://www.ncbi.nlm.nih.gov/pubmed/10631169?dopt=Abstract&lt;/p&gt;
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