<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Chaube, S.</style></author><author><style face="normal" font="default" size="100%">Swinyard, C. A.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Teratological and toxicological studies of alkaloidal and phenolic compounds from Solanum Tuberosum </style></title><short-title><style face="normal" font="default" size="100%">Toxicology and Applied Pharmacology</style></short-title></titles><dates><year><style  face="normal" font="default" size="100%">1976</style></year><pub-dates><date><style  face="normal" font="default" size="100%">01/1976</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.sciencedirect.com/science/article/pii/0041008X76900028</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">36</style></volume><pages><style face="normal" font="default" size="100%">227 - 237</style></pages><isbn><style face="normal" font="default" size="100%">0041-008X</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;A comparative study of acute and chronic ip administration was made in pregnant and nonpregnant (female) rats of alkaloidal (α-chaconine, α-solanine total glycoalkaloidal extract (TGA-extract)) and phenolic compounds (chlorogenic and caffeic acid) from Solanum Tuberosum L. The acute LD50 and 95% confidence limits for α-chaconine, α-solanine, and the TGA-extract were 84 (65.6–107.5), 67 (52.3–85.7), and 60 mg/kg (35.7–100.8). There was no significant difference in their potency at the 95% confidence limit. Chronic adminstration of α-chaconine, α-solanine, and the TGA-extract to nonpregnant rats for 2 days (40 mg/kg/day) and 8 days (20 mg/kg/day) resulted in 40 and 42% mortality, respectively. Eight daily injections of α-chaconine (5–20 mg/kg) on Days 5–12 or 2 (40 mg/kg) on Days 5 and 6 to pregnant rats resulted in maternal (40–66%) and fetal death (15–100%), whereas α-solanine and the TGA-extract administered similarly were lethal only to the fetus (17–86%). Eight daily injections of chlorogenic (5–500 mg/kg) and caffeic acid (40–187.5 mg/kg) on Days 5–12 of gestation did not cause maternal or fetal lethality. None of the compounds tested produced neural tube defects, but a few 21-day-old fetuses had rib abnormalities.&lt;/p&gt;
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