<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kaimen-Maciel, Damacio R</style></author><author><style face="normal" font="default" size="100%">Reiche, Edna Maria V</style></author><author><style face="normal" font="default" size="100%">Borelli, Sueli D</style></author><author><style face="normal" font="default" size="100%">Morimoto, Helena K</style></author><author><style face="normal" font="default" size="100%">Melo, Fabiano C</style></author><author><style face="normal" font="default" size="100%">Lopes, Josiane</style></author><author><style face="normal" font="default" size="100%">Dorigon, Raffael F</style></author><author><style face="normal" font="default" size="100%">Cavalet, Christiane</style></author><author><style face="normal" font="default" size="100%">Yamaguchi, Elton M</style></author><author><style face="normal" font="default" size="100%">Silveira, Thiago L</style></author><author><style face="normal" font="default" size="100%">Da Silva, Waldir V</style></author><author><style face="normal" font="default" size="100%">Comini-Frota, Elizabeth R</style></author><author><style face="normal" font="default" size="100%">Brum Souza, Doralina G</style></author><author><style face="normal" font="default" size="100%">Donadi, Eduardo A</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">HLA-DRB1* allele-associated genetic susceptibility and protection against multiple sclerosis in Brazilian patients.</style></title><secondary-title><style face="normal" font="default" size="100%">Mol Med Rep</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Mol Med Rep</style></alt-title></titles><dates><year><style  face="normal" font="default" size="100%">2009</style></year><pub-dates><date><style  face="normal" font="default" size="100%">11/2009</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">2</style></volume><pages><style face="normal" font="default" size="100%">993-8</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Multiple sclerosis (MS) is a chronic autoimmune demyelinating disease of the central nervous system that causes neurological disorders in young adults. Previous studies in various populations highlighted an association between the HLA-DRB1*15 allele and MS. This study investigated the association between HLA-DRB1*15 and other HLA-DRB1 alleles and MS in a Brazilian Caucasian population sample from Londrina, Southern Brazil. HLA-DRB1 alleles were analyzed by polymerase chain reaction with specific sequence oligonucleotide primers in 119 MS patients and in 305 healthy blood donors as a control. Among the MS patients, 89 (75.0%) presented with relapsing remitting MS, 24 (20.0%) with secondary progressive MS and 6 (5.0%) with primary progressive MS. The frequency of the HLA-DRB1*15 allele observed in the MS Brazilian patients was similar to findings reported in previous studies carried out in populations worldwide. However, the results showed a higher frequency of the HLA-DRB1*15 allele in the MS patients compared to the controls, with a relative frequency of 0.1050 (10.50%) and 0.0443 (4.4%), respectively (OR=2.53; 95% CI 1.43-4.46; p=0.0009). A protector allele was also detected. The frequency of the HLA-DRB1*11 allele was reduced in the MS patients compared to the controls, with a relative frequency of 0.1345 (13.4%) and 0.1869 (18.7%), respectively (OR=0.67; 95% CI 0.44-1.03; p=0.0692). The results demonstrated that the HLA-DRB1*15 allele in heterozygosity is positively associated with MS (p=0.0079), and may be considered a genetic marker of susceptibility to the disease. A negative association between the HLA-DRB1*11 allele in homozygosity and MS was also verified (p=0.0418); this allele may be considered a genetic marker of resistance to MS in the Brazilian population.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><custom1><style face="normal" font="default" size="100%">&lt;p&gt;http://www.ncbi.nlm.nih.gov/pubmed/21475933?dopt=Abstract&lt;/p&gt;
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