<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Winckler, W.</style></author><author><style face="normal" font="default" size="100%">Myers, S. R.</style></author><author><style face="normal" font="default" size="100%">Richter, D. J.</style></author><author><style face="normal" font="default" size="100%">Onofrio, R. C.</style></author><author><style face="normal" font="default" size="100%">McDonald, G. J.</style></author><author><style face="normal" font="default" size="100%">Bontrop, R. E.</style></author><author><style face="normal" font="default" size="100%">McVean, G. A. T.</style></author><author><style face="normal" font="default" size="100%">Gabriel, S. B.</style></author><author><style face="normal" font="default" size="100%">Reich, D.</style></author><author><style face="normal" font="default" size="100%">Donnelly, P.</style></author><author><style face="normal" font="default" size="100%">Altshuler, D.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparison of fine-scale recombination rates in humans and chimpanzees.</style></title><secondary-title><style face="normal" font="default" size="100%">Science</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Science</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Alleles</style></keyword><keyword><style  face="normal" font="default" size="100%">Animals</style></keyword><keyword><style  face="normal" font="default" size="100%">Base Sequence</style></keyword><keyword><style  face="normal" font="default" size="100%">Chromosome Mapping</style></keyword><keyword><style  face="normal" font="default" size="100%">Chromosomes, Human</style></keyword><keyword><style  face="normal" font="default" size="100%">Chromosomes, Mammalian</style></keyword><keyword><style  face="normal" font="default" size="100%">Evolution, Molecular</style></keyword><keyword><style  face="normal" font="default" size="100%">Genome</style></keyword><keyword><style  face="normal" font="default" size="100%">Genome, Human</style></keyword><keyword><style  face="normal" font="default" size="100%">Genotype</style></keyword><keyword><style  face="normal" font="default" size="100%">Globins</style></keyword><keyword><style  face="normal" font="default" size="100%">Haplotypes</style></keyword><keyword><style  face="normal" font="default" size="100%">HLA Antigens</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Linkage Disequilibrium</style></keyword><keyword><style  face="normal" font="default" size="100%">Markov Chains</style></keyword><keyword><style  face="normal" font="default" size="100%">Monte Carlo Method</style></keyword><keyword><style  face="normal" font="default" size="100%">Pan troglodytes</style></keyword><keyword><style  face="normal" font="default" size="100%">Polymorphism, Single Nucleotide</style></keyword><keyword><style  face="normal" font="default" size="100%">Recombination, Genetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Sequence Homology, Nucleic Acid</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2005</style></year><pub-dates><date><style  face="normal" font="default" size="100%">04/2005</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">308</style></volume><pages><style face="normal" font="default" size="100%">107-11</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;We compared fine-scale recombination rates at orthologous loci in humans and chimpanzees by analyzing polymorphism data in both species. Strong statistical evidence for hotspots of recombination was obtained in both species. Despite approximately 99% identity at the level of DNA sequence, however, recombination hotspots were found rarely (if at all) at the same positions in the two species, and no correlation was observed in estimates of fine-scale recombination rates. Thus, local patterns of recombination rate have evolved rapidly, in a manner disproportionate to the change in DNA sequence.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5718</style></issue><custom1><style face="normal" font="default" size="100%">&lt;p&gt;http://www.ncbi.nlm.nih.gov/pubmed/15705809?dopt=Abstract&lt;/p&gt;
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