<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Persson, Mia E.</style></author><author><style face="normal" font="default" size="100%">Wright, Dominic</style></author><author><style face="normal" font="default" size="100%">Roth, Lina S. V.</style></author><author><style face="normal" font="default" size="100%">Batakis, Petros</style></author><author><style face="normal" font="default" size="100%">Jensen, Per</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Genomic Regions Associated With Interspecies Communication in Dogs Contain Genes Related to Human Social Disorders</style></title><secondary-title><style face="normal" font="default" size="100%">Scientific Reports</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2016/09/29</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.nature.com/articles/srep33439</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">6</style></volume><pages><style face="normal" font="default" size="100%">33439 - </style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Unlike their wolf ancestors, dogs have unique social skills for communicating and cooperating with humans. Previously, significant heritabilities for human-directed social behaviors have been found in laboratory beagles. Here, a Genome-Wide Association Study identified two genomic regions associated with dog’s human-directed social behaviors. We recorded the propensity of laboratory beagles, bred, kept and handled under standardized conditions, to initiate physical interactions with a human during an unsolvable problem-task, and 190 individuals were genotyped with an HD Canine SNP-chip. One genetic marker on chromosome 26 within the &lt;i&gt;SEZ6L&lt;/i&gt; gene was significantly associated with time spent close to, and in physical contact with, the human. Two suggestive markers on chromosome 26, located within the &lt;i&gt;ARVCF&lt;/i&gt; gene, were also associated with human contact seeking. Strikingly, four additional genes present in the same linkage blocks affect social abilities in humans, e.g., &lt;i&gt;SEZ6L&lt;/i&gt; has been associated with autism and &lt;i&gt;COMT&lt;/i&gt; affects aggression in adolescents with ADHD. This is, to our knowledge, the first genome-wide study presenting candidate genomic regions for dog sociability and inter-species communication. These results advance our understanding of dog domestication and raise the use of the dog as a novel model system for human social disorders.&lt;/p&gt;
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