<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Changeux, JP</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Climbing Brain Levels of Organisation from Genes to Consciousness.</style></title><secondary-title><style face="normal" font="default" size="100%">Trends Cogn Sci</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Mar</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">https://www.ncbi.nlm.nih.gov/pubmed/28161289</style></url></web-urls></urls><number><style face="normal" font="default" size="100%">3</style></number><volume><style face="normal" font="default" size="100%">21</style></volume><pages><style face="normal" font="default" size="100%">168-181</style></pages><isbn><style face="normal" font="default" size="100%">1364-6613</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Given the tremendous complexity of brain organisation, here I propose a strategy that dynamically links stages of brain organisation from genes to consciousness, at four privileged structural levels: genes; transcription factors (TFs)-gene networks; synaptic epigenesis; and long-range connectivity. These structures are viewed as nested and reciprocally inter-regulated, with a hierarchical organisation that proceeds on different timescales during the course of evolution and development. Interlevel bridging mechanisms include intrinsic variation-selection mechanisms, which offer a community of bottom-up and top-down models linking genes to consciousness in a stepwise manner.&lt;/p&gt;
</style></abstract><accession-num><style face="normal" font="default" size="100%">28161289</style></accession-num><auth-address><style face="normal" font="default" size="100%">Collège de France and CNRS UMR 3571, Institut Pasteur, Paris, France. Electronic address: changeux@noos.fr.</style></auth-address></record></records></xml>