<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Xu, Duo</style></author><author><style face="normal" font="default" size="100%">Pavlidis, Pavlos</style></author><author><style face="normal" font="default" size="100%">Taskent, Recep Ozgur</style></author><author><style face="normal" font="default" size="100%">Alachiotis, Nikolaos</style></author><author><style face="normal" font="default" size="100%">Flanagan, Colin</style></author><author><style face="normal" font="default" size="100%">DeGiorgio, Michael</style></author><author><style face="normal" font="default" size="100%">Blekhman, Ran</style></author><author><style face="normal" font="default" size="100%">Ruhl, Stefan</style></author><author><style face="normal" font="default" size="100%">Gokcumen, Omer</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Archaic hominin introgression in Africa contributes to functional salivary MUC7 genetic variation</style></title><secondary-title><style face="normal" font="default" size="100%">Molecular Biology and Evolution</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2017</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">https://academic.oup.com/mbe/article/3988100/Archaic-hominin-introgression-in-Africa?searchresult=1</style></url></web-urls></urls><pages><style face="normal" font="default" size="100%">msx206</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;span style=&quot;color: rgb(42, 42, 42); font-family: Merriweather, serif; background-color: rgb(239, 242, 247);&quot;&gt;One of the most abundant proteins in human saliva, mucin-7, is encoded by the&amp;nbsp;&lt;/span&gt;&lt;em style=&quot;box-sizing: border-box; margin: 0px; padding: 0px; border: 0px; font-family: Merriweather, serif; line-height: inherit; vertical-align: baseline; color: rgb(42, 42, 42);&quot;&gt;MUC7&lt;/em&gt;&lt;span style=&quot;color: rgb(42, 42, 42); font-family: Merriweather, serif; background-color: rgb(239, 242, 247);&quot;&gt;&amp;nbsp;gene, which harbors copy number variable subexonic repeats (PTS-repeats) that affect the size and glycosylation potential of this protein. We recently documented the adaptive evolution of&amp;nbsp;&lt;/span&gt;&lt;em style=&quot;box-sizing: border-box; margin: 0px; padding: 0px; border: 0px; font-family: Merriweather, serif; line-height: inherit; vertical-align: baseline; color: rgb(42, 42, 42);&quot;&gt;MUC7&lt;/em&gt;&lt;span style=&quot;color: rgb(42, 42, 42); font-family: Merriweather, serif; background-color: rgb(239, 242, 247);&quot;&gt;&amp;nbsp;subexonic copy number variation among primates. Yet, the evolution of&amp;nbsp;&lt;/span&gt;&lt;em style=&quot;box-sizing: border-box; margin: 0px; padding: 0px; border: 0px; font-family: Merriweather, serif; line-height: inherit; vertical-align: baseline; color: rgb(42, 42, 42);&quot;&gt;MUC7&lt;/em&gt;&lt;span style=&quot;color: rgb(42, 42, 42); font-family: Merriweather, serif; background-color: rgb(239, 242, 247);&quot;&gt;&amp;nbsp;genetic variation in humans remained unexplored. Here, we found that PTS-repeat copy number variation has evolved recurrently in the human lineage, thereby generating multiple haplotypic backgrounds carrying 5 or 6 PTS-repeat copy number alleles. Contrary to previous studies, we found no associations between the copy number of PTS-repeat copy number and protection against asthma. Instead, we revealed a significant association of&amp;nbsp;&lt;/span&gt;&lt;em style=&quot;box-sizing: border-box; margin: 0px; padding: 0px; border: 0px; font-family: Merriweather, serif; line-height: inherit; vertical-align: baseline; color: rgb(42, 42, 42);&quot;&gt;MUC7&lt;/em&gt;&lt;span style=&quot;color: rgb(42, 42, 42); font-family: Merriweather, serif; background-color: rgb(239, 242, 247);&quot;&gt;&amp;nbsp;haplotypic variation with the composition of the oral microbiome. Furthermore, based on in-depth simulations, we conclude that a divergent&amp;nbsp;&lt;/span&gt;&lt;em style=&quot;box-sizing: border-box; margin: 0px; padding: 0px; border: 0px; font-family: Merriweather, serif; line-height: inherit; vertical-align: baseline; color: rgb(42, 42, 42);&quot;&gt;MUC7&lt;/em&gt;&lt;span style=&quot;color: rgb(42, 42, 42); font-family: Merriweather, serif; background-color: rgb(239, 242, 247);&quot;&gt;&amp;nbsp;haplotype likely originated in an unknown African hominin population and introgressed into ancestors of modern Africans.&lt;/span&gt;&lt;/p&gt;
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