<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Fothergill, Erin</style></author><author><style face="normal" font="default" size="100%">Guo, Juen</style></author><author><style face="normal" font="default" size="100%">Howard, Lilian</style></author><author><style face="normal" font="default" size="100%">Kerns, Jennifer C</style></author><author><style face="normal" font="default" size="100%">Knuth, Nicolas D</style></author><author><style face="normal" font="default" size="100%">Brychta, Robert</style></author><author><style face="normal" font="default" size="100%">Chen, Kong Y</style></author><author><style face="normal" font="default" size="100%">Skarulis, Monica C</style></author><author><style face="normal" font="default" size="100%">Walter, Mary</style></author><author><style face="normal" font="default" size="100%">Walter, Peter J</style></author><author><style face="normal" font="default" size="100%">Hall, Kevin D</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Persistent metabolic adaptation 6 years after &quot;The Biggest Loser&quot; competition.</style></title><secondary-title><style face="normal" font="default" size="100%">Obesity (Silver Spring)</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Obesity (Silver Spring)</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Absorptiometry, Photon</style></keyword><keyword><style  face="normal" font="default" size="100%">Adult</style></keyword><keyword><style  face="normal" font="default" size="100%">Basal Metabolism</style></keyword><keyword><style  face="normal" font="default" size="100%">Body composition</style></keyword><keyword><style  face="normal" font="default" size="100%">Body Mass Index</style></keyword><keyword><style  face="normal" font="default" size="100%">Body Weight</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Follow-Up Studies</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">Middle Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Obesity, Morbid</style></keyword><keyword><style  face="normal" font="default" size="100%">Weight Loss</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2016 Aug</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://onlinelibrary.wiley.com/doi/10.1002/oby.21538/abstract</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">24</style></volume><pages><style face="normal" font="default" size="100%">1612-9</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;b&gt;OBJECTIVE: &lt;/b&gt;To measure long-term changes in resting metabolic rate (RMR) and body composition in participants of &quot;The Biggest Loser&quot; competition.&lt;/p&gt;

&lt;p&gt;&lt;b&gt;METHODS: &lt;/b&gt;Body composition was measured by dual energy X-ray absorptiometry, and RMR was determined by indirect calorimetry at baseline, at the end of the 30-week competition and 6 years later. Metabolic adaptation was defined as the residual RMR after adjusting for changes in body composition and age.&lt;/p&gt;

&lt;p&gt;&lt;b&gt;RESULTS: &lt;/b&gt;Of the 16 &quot;Biggest Loser&quot; competitors originally investigated, 14 participated in this follow-up study. Weight loss at the end of the competition was (mean ± SD) 58.3 ± 24.9 kg (P &amp;lt; 0.0001), and RMR decreased by 610 ± 483 kcal/day (P = 0.0004). After 6 years, 41.0 ± 31.3 kg of the lost weight was regained (P = 0.0002), while RMR was 704 ± 427 kcal/day below baseline (P &amp;lt; 0.0001) and metabolic adaptation was -499 ± 207 kcal/day (P &amp;lt; 0.0001). Weight regain was not significantly correlated with metabolic adaptation at the competition&#039;s end (r = -0.1, P = 0.75), but those subjects maintaining greater weight loss at 6 years also experienced greater concurrent metabolic slowing (r = 0.59, P = 0.025).&lt;/p&gt;

&lt;p&gt;&lt;b&gt;CONCLUSIONS: &lt;/b&gt;Metabolic adaptation persists over time and is likely a proportional, but incomplete, response to contemporaneous efforts to reduce body weight.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">8</style></issue><custom1><style face="normal" font="default" size="100%">&lt;p&gt;http://www.ncbi.nlm.nih.gov/pubmed/27136388?dopt=Abstract&lt;/p&gt;
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