<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Siddiqui, SS</style></author><author><style face="normal" font="default" size="100%">Springer, SA</style></author><author><style face="normal" font="default" size="100%">Verhagen, A</style></author><author><style face="normal" font="default" size="100%">Sundaramurthy, V</style></author><author><style face="normal" font="default" size="100%">Alisson-Silva, F</style></author><author><style face="normal" font="default" size="100%">Jiang, W</style></author><author><style face="normal" font="default" size="100%">Ghosh, P</style></author><author><style face="normal" font="default" size="100%">Ajit Varki</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Alzheimer&#039;s disease–protective CD33 splice variant mediates adaptive loss of function via diversion to an intracellular pool</style></title><secondary-title><style face="normal" font="default" size="100%">J Biol Chem</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2017</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.jbc.org/content/292/37/15312.full</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">292</style></volume><pages><style face="normal" font="default" size="100%">15312-15320</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;The immunomodulatory receptor Siglec-3/CD33 influences risk for late-onset Alzheimer&#039;s disease (LOAD), an apparently human-specific post-reproductive disease. CD33 generates two splice variants: a full-length CD33M transcript produced primarily by the “LOAD-risk” allele and a shorter CD33m isoform lacking the sialic acid-binding domain produced primarily from the “LOAD-protective” allele. An SNP that modulates CD33 splicing to favor CD33m is associated with enhanced microglial activity. Individuals expressing more&amp;nbsp;…&lt;/p&gt;
</style></abstract><notes><style face="normal" font="default" size="100%">&lt;p&gt;Times cited: 1&lt;/p&gt;
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