<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Changeux, JP</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Structural Identification of the Nicotinic Receptor Ion Channel.</style></title><secondary-title><style face="normal" font="default" size="100%">Trends Neurosci</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Feb</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">https://www.ncbi.nlm.nih.gov/pubmed/29405928</style></url></web-urls></urls><number><style face="normal" font="default" size="100%">2</style></number><volume><style face="normal" font="default" size="100%">41</style></volume><pages><style face="normal" font="default" size="100%">67-70</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;The structural identification of the cationic channel of the acetylcholine nicotinic receptor involved its biochemical tagging by channel blockers, followed by site-directed mutagenesis analyses reported in two papers in 1988. The ion channel was demonstrated to be lined by the transmembrane segment MII, in which the binding sites of channel blockers are &quot;framed&quot; by anionic rings.&lt;/p&gt;
</style></abstract><accession-num><style face="normal" font="default" size="100%">29405928</style></accession-num><auth-address><style face="normal" font="default" size="100%">CNRS UMR 3571, Institut Pasteur, Paris F-75724 Cedex 15, France; Chaire de Communications Cellulaires, Collège de France, Paris F-75005, France. Electronic address: changeux@noos.fr.</style></auth-address></record></records></xml>