<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kalebic, N</style></author><author><style face="normal" font="default" size="100%">Gilardi, C</style></author><author><style face="normal" font="default" size="100%">Stepien, B</style></author><author><style face="normal" font="default" size="100%">Wilsch-Bräuninger, M</style></author><author><style face="normal" font="default" size="100%">Long, KR</style></author><author><style face="normal" font="default" size="100%">Namba, T</style></author><author><style face="normal" font="default" size="100%">Florio, M</style></author><author><style face="normal" font="default" size="100%">Langen, B</style></author><author><style face="normal" font="default" size="100%">Lombardot, B</style></author><author><style face="normal" font="default" size="100%">Shevchenko, A</style></author><author><style face="normal" font="default" size="100%">Kilimann, MW</style></author><author><style face="normal" font="default" size="100%">Kawasaki, H</style></author><author><style face="normal" font="default" size="100%">Wimberger, P</style></author><author><style face="normal" font="default" size="100%">Huttner, WB</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Neocortical Expansion Due to Increased Proliferation of Basal Progenitors Is Linked to Changes in Their Morphology.</style></title><secondary-title><style face="normal" font="default" size="100%">Cell Stem Cell</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Cell Stem Cell</style></alt-title></titles><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2019 Apr 04</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">24</style></volume><pages><style face="normal" font="default" size="100%">535-550.e9</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;The evolutionary expansion of the mammalian neocortex (Ncx) is thought to be linked to increased proliferative capacity of basal progenitors (BPs) and their neurogenic capacity. Here, by quantifying BP&amp;nbsp;morphology in the developing Ncx of mouse, ferret, and human, we show that increased BP proliferative capacity is linked to an increase in BP process number. We identify human membrane-bound PALMDELPHIN (PALMD-Caax) as an underlying factor, and we show that it drives BP process growth and proliferation when expressed in developing mouse and ferret Ncx. Conversely, CRISPR/Cas9-mediated disruption of PALMD or its binding partner ADDUCIN-γ in fetal human Ncx reduces BP process numbers and proliferation. We further show that PALMD-induced processes enable BPs to receive pro-proliferative integrin-dependent signals. These findings provide a link between BP morphology and proliferation, suggesting that changes in BP morphology may have contributed to the evolutionary expansion of the Ncx.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><custom1><style face="normal" font="default" size="100%">&lt;p&gt;https://www.ncbi.nlm.nih.gov/pubmed/30905618?dopt=Abstract&lt;/p&gt;
</style></custom1></record></records></xml>