<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Fiddes, Ian T</style></author><author><style face="normal" font="default" size="100%">Pollen, Alex A</style></author><author><style face="normal" font="default" size="100%">Davis, Jonathan M</style></author><author><style face="normal" font="default" size="100%">Sikela, James M</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Paired involvement of human-specific Olduvai domains and NOTCH2NL genes in human brain evolution</style></title><secondary-title><style face="normal" font="default" size="100%">Human Genetics</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">05/2019</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">https://link.springer.com/article/10.1007%2Fs00439-019-02018-4</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">138</style></volume><pages><style face="normal" font="default" size="100%">1-7</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Sequences encoding &lt;span class=&quot;highlight&quot; style=&quot;background-color:&quot;&gt;Olduvai&lt;/span&gt; (DUF1220) protein &lt;span class=&quot;highlight&quot; style=&quot;background-color:&quot;&gt;domains&lt;/span&gt; show the largest &lt;span class=&quot;highlight&quot; style=&quot;background-color:&quot;&gt;human-specific&lt;/span&gt; increase in copy number of any coding region in the genome and have been linked to &lt;span class=&quot;highlight&quot; style=&quot;background-color:&quot;&gt;human&lt;/span&gt; &lt;span class=&quot;highlight&quot; style=&quot;background-color:&quot;&gt;brain&lt;/span&gt; &lt;span class=&quot;highlight&quot; style=&quot;background-color:&quot;&gt;evolution&lt;/span&gt;. Most &lt;span class=&quot;highlight&quot; style=&quot;background-color:&quot;&gt;human-specific&lt;/span&gt; copies of &lt;span class=&quot;highlight&quot; style=&quot;background-color:&quot;&gt;Olduvai&lt;/span&gt; (119/165) are encoded by three NBPF &lt;span class=&quot;highlight&quot; style=&quot;background-color:&quot;&gt;genes&lt;/span&gt; that are adjacent to three &lt;span class=&quot;highlight&quot; style=&quot;background-color:&quot;&gt;human-specific&lt;/span&gt; &lt;span class=&quot;highlight&quot; style=&quot;background-color:&quot;&gt;NOTCH2NL&lt;/span&gt; &lt;span class=&quot;highlight&quot; style=&quot;background-color:&quot;&gt;genes&lt;/span&gt; that have been shown to promote cortical neurogenesis. Here, employing genomic, phylogenetic, and transcriptomic evidence, we show that these &lt;span class=&quot;highlight&quot; style=&quot;background-color:&quot;&gt;NOTCH2NL&lt;/span&gt;/NBPF gene pairs evolved jointly, as two-gene units, very recently in &lt;span class=&quot;highlight&quot; style=&quot;background-color:&quot;&gt;human&lt;/span&gt; &lt;span class=&quot;highlight&quot; style=&quot;background-color:&quot;&gt;evolution&lt;/span&gt;, and are likely co-regulated. Remarkably, while three &lt;span class=&quot;highlight&quot; style=&quot;background-color:&quot;&gt;NOTCH2NL&lt;/span&gt; paralogs were added, adjacent &lt;span class=&quot;highlight&quot; style=&quot;background-color:&quot;&gt;Olduvai&lt;/span&gt; sequences hyper-amplified, adding 119 &lt;span class=&quot;highlight&quot; style=&quot;background-color:&quot;&gt;human-specific&lt;/span&gt; copies. The data suggest that &lt;span class=&quot;highlight&quot; style=&quot;background-color:&quot;&gt;human-specific&lt;/span&gt; &lt;span class=&quot;highlight&quot; style=&quot;background-color:&quot;&gt;Olduvai&lt;/span&gt; &lt;span class=&quot;highlight&quot; style=&quot;background-color:&quot;&gt;domains&lt;/span&gt; and adjacent &lt;span class=&quot;highlight&quot; style=&quot;background-color:&quot;&gt;NOTCH2NL&lt;/span&gt; &lt;span class=&quot;highlight&quot; style=&quot;background-color:&quot;&gt;genes&lt;/span&gt; may function in a coordinated, complementary fashion to promote neurogenesis and &lt;span class=&quot;highlight&quot; style=&quot;background-color:&quot;&gt;human&lt;/span&gt; &lt;span class=&quot;highlight&quot; style=&quot;background-color:&quot;&gt;brain&lt;/span&gt; expansion in a dosage-related manner.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">656</style></issue></record></records></xml>