<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Zanella, Matteo</style></author><author><style face="normal" font="default" size="100%">Vitriolo, Alessandro</style></author><author><style face="normal" font="default" size="100%">Andirko, Alejandro</style></author><author><style face="normal" font="default" size="100%">Martins, Pedro Tiago</style></author><author><style face="normal" font="default" size="100%">Sturm, Stefanie</style></author><author><style face="normal" font="default" size="100%">O&#039;Rourke, Thomas</style></author><author><style face="normal" font="default" size="100%">Laugsch, Magdalena</style></author><author><style face="normal" font="default" size="100%">Malerba, Natascia</style></author><author><style face="normal" font="default" size="100%">Skaros, Adrianos</style></author><author><style face="normal" font="default" size="100%">Trattaro, Sebastiano</style></author><author><style face="normal" font="default" size="100%">Germain, Pierre-Luc</style></author><author><style face="normal" font="default" size="100%">Mihailovic, Marija</style></author><author><style face="normal" font="default" size="100%">Merla, Giuseppe</style></author><author><style face="normal" font="default" size="100%">Rada-Iglesias, Alvaro</style></author><author><style face="normal" font="default" size="100%">Boeckx, Cedric</style></author><author><style face="normal" font="default" size="100%">Testa, Giuseppe</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Dosage analysis of the 7q11.23 Williams region identifies as a major human gene patterning the modern human face and underlying self-domestication.</style></title><secondary-title><style face="normal" font="default" size="100%">Sci Adv</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Sci Adv</style></alt-title></titles><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2019 12</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">5</style></volume><pages><style face="normal" font="default" size="100%">eaaw7908</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;We undertook a functional dissection of chromatin remodeler BAZ1B in neural crest (NC) stem cells (NCSCs) from a uniquely informative cohort of typical and atypical patients harboring 7q11.23 copy number variants. Our results reveal a key contribution of BAZ1B to NCSC in vitro induction and migration, coupled with a crucial involvement in NC-specific transcriptional circuits and distal regulation. By intersecting our experimental data with new paleogenetic analyses comparing modern and archaic humans, we found a modern-specific enrichment for regulatory changes both in BAZ1B and its experimentally defined downstream targets, thereby providing the first empirical validation of the human self-domestication hypothesis and positioning BAZ1B as a master regulator of the modern human face. In so doing, we provide experimental evidence that the craniofacial and cognitive/behavioral phenotypes caused by alterations of the Williams-Beuren syndrome critical region can serve as a powerful entry point into the evolution of the modern human face and prosociality.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">12</style></issue><custom1><style face="normal" font="default" size="100%">&lt;p&gt;https://www.ncbi.nlm.nih.gov/pubmed/31840056?dopt=Abstract&lt;/p&gt;
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