<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Haghani, Amin</style></author><author><style face="normal" font="default" size="100%">Thorwald, Max</style></author><author><style face="normal" font="default" size="100%">Morgan, Todd E</style></author><author><style face="normal" font="default" size="100%">Finch, Caleb E</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The APOE gene cluster responds to air pollution factors in mice with coordinated expression of genes that differs by age in humans.</style></title><secondary-title><style face="normal" font="default" size="100%">Alzheimers Dement</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Alzheimers Dement</style></alt-title></titles><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2020 Nov 20</style></date></pub-dates></dates><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Little is known of gene-environment interactions for Alzheimer&#039;s disease (AD) risk factors. Apolipoprotein E (APOE) and neighbors on chromosome 19q13.3 have variants associated with risks of AD, but with unknown mechanism. This study describes novel links among the APOE network, air pollution, and age-related diseases. Mice exposed to air pollution nano-sized particulate matter (nPM) had coordinate responses of Apoe-Apoc1-Tomm40 in the cerebral cortex. In humans, the AD vulnerable hippocampus and amygdala had stronger age decline in APOE cluster expression than the AD-resistant cerebellum and hypothalamus. Using consensus weighted gene co-expression network, we showed that APOE has a conserved co-expressed network in rodent and primate brains. SOX1, which has AD-associated single nucleotide polymorphisms, was among the co-expressed genes in the human hippocampus. Humans and mice shared 87% of potential binding sites for transcription factors in APOE cluster promoter, suggesting similar inducibility and a novel link among environment, APOE cluster, and risk of AD.&lt;/p&gt;
</style></abstract><custom1><style face="normal" font="default" size="100%">&lt;p&gt;https://www.ncbi.nlm.nih.gov/pubmed/33215813?dopt=Abstract&lt;/p&gt;
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